دواعي استعمال ريباجليد 0.5مجم 20 اقراص

Repaglinide 0.5 mg tablets, pack of 20; short-acting insulin secretagogue for type 2 diabetes.

• Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.الفئة: AdultsDailyMed (U.S. National Library of Medicine)

• Hypoglycemia, upper respiratory infection, headache, sinusitis, arthralgia, nausea, diarrhea and back pain.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Concomitant use with gemfibrozil.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Known hypersensitivity to repaglinide or inactive ingredients.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Hypoglycemia, which may be severe; risk increased with renal/hepatic impairment, missed meals, alcohol or other glucose-lowering drugs.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Not recommended in combination with NPH insulin.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• No clinical studies establish macrovascular risk reduction.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• GemfibrozilContraindicated: markedly increased repaglinide exposure.DailyMed (U.S. National Library of Medicine)
• ClopidogrelIncreased exposure; avoid, or limit total daily repaglinide to 4 mg.DailyMed (U.S. National Library of Medicine)
• CyclosporineIncreased exposure; limit daily repaglinide to 6 mg.DailyMed (U.S. National Library of Medicine)
• Strong CYP2C8/CYP3A4 inhibitors or inducersMay raise or lower repaglinide levels; adjust dose and monitor glucose.DailyMed (U.S. National Library of Medicine)
• Beta-blockersMay mask signs of hypoglycemia.DailyMed (U.S. National Library of Medicine)

• Limited data have not identified a drug-associated risk of major birth defects or miscarriage; poorly controlled diabetes carries maternal and fetal risks.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Breastfeeding is not recommended during treatment because of potential neonatal hypoglycemia.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Closes ATP-dependent potassium channels in pancreatic beta cells, stimulating glucose-dependent insulin release.