دواعي استعمال ريبليتزا 1/500مجم 30 اقراص

Replitza 1/500 mg film-coated tablets (30 tablets): fixed-dose combination of repaglinide 1 mg and metformin 500 mg for type 2 diabetes; listed in Egypt under Marcyrl Co. > Ecco Pharm-Egypt.

• Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes already treated with a meglitinide and metformin, or inadequately controlled on either alone (per US PrandiMet label).الفئة: Adults with type 2 diabetesNovo Nordisk

• Hypoglycemia and headache were the most common adverse reactions (>=10%) with repaglinide plus metformin; gastrointestinal reactions (diarrhea, nausea, vomiting) are the most common with metformin and are dose-related.نشرة دولية لنفس التركيبة · Novo Nordisk

• Renal impairment.نشرة دولية لنفس التركيبة · Novo Nordisk
• Metabolic acidosis, including diabetic ketoacidosis.نشرة دولية لنفس التركيبة · Novo Nordisk
• Concomitant gemfibrozil.نشرة دولية لنفس التركيبة · Novo Nordisk

• Boxed warning: lactic acidosis due to metformin accumulation; risk increases with sepsis, dehydration, excess alcohol, hepatic or renal impairment and acute heart failure; discontinue and hospitalize if suspected.نشرة دولية لنفس التركيبة · Novo Nordisk
• The repaglinide component can cause hypoglycemia; start at the lowest dose in meglitinide-naive patients.نشرة دولية لنفس التركيبة · Novo Nordisk
• Metformin can cause vitamin B12 deficiency; measure hematological parameters annually.نشرة دولية لنفس التركيبة · Novo Nordisk
• Not for use with NPH insulin; temporary insulin may be needed during stress (infection, surgery); hold around iodinated contrast studies.نشرة دولية لنفس التركيبة · Novo Nordisk

• GemfibrozilContraindicated: substantially increases repaglinide exposure (more than 20-fold with gemfibrozil plus itraconazole).Novo Nordisk
• CYP2C8/CYP3A4 inhibitors or inducersMay alter repaglinide exposure.Novo Nordisk
• Cationic drugs eliminated by renal tubular secretionMay interfere with metformin elimination.Novo Nordisk

• No adequate well-controlled studies in pregnant women with the combination or its components; use during pregnancy only if clearly needed (2012 US label).نشرة دولية لنفس التركيبة · Novo Nordisk
• Both repaglinide and metformin are excreted into the milk of lactating rats; no studies with the fixed combination.نشرة دولية لنفس التركيبة · Novo Nordisk

• Monitor renal function, glycemic control and hematological parameters (vitamin B12) at least annually.نشرة دولية لنفس التركيبة · Novo Nordisk