دواعي استعمال ريبليتزا 2/500مجم 30 اقراص

Fixed-dose oral antidiabetic tablet combining repaglinide 2 mg (meglitinide insulin secretagogue) and metformin 500 mg (biguanide); pack of 30 film-coated tablets.

• Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes already treated with a meglitinide and metformin, or inadequately controlled on either alone.الفئة: AdultsNovo Nordisk (novo-pi.com)

• Hypoglycemia and headache were the most common adverse reactions (>=10%) with repaglinide plus metformin; diarrhea, nausea and vomiting are the most common metformin reactions.نشرة دولية لنفس التركيبة · Novo Nordisk (novo-pi.com)

• Renal impairment (e.g., serum creatinine >=1.5 mg/dL in males, >=1.4 mg/dL in females, or abnormal creatinine clearance).نشرة دولية لنفس التركيبة · Novo Nordisk (novo-pi.com)
• Acute or chronic metabolic acidosis, including diabetic ketoacidosis.نشرة دولية لنفس التركيبة · Novo Nordisk (novo-pi.com)
• Concomitant gemfibrozil.نشرة دولية لنفس التركيبة · Novo Nordisk (novo-pi.com)
• Known hypersensitivity to repaglinide, metformin HCl or any inactive ingredient.نشرة دولية لنفس التركيبة · Novo Nordisk (novo-pi.com)

• Boxed warning: lactic acidosis, a rare but serious complication due to metformin accumulation; risk increases with renal impairment, hepatic impairment, hypoxic states, excess alcohol and age.نشرة دولية لنفس التركيبة · Novo Nordisk (novo-pi.com)
• Repaglinide can cause hypoglycemia; start at the lowest dose in meglitinide-naive patients. Do not combine with NPH insulin.نشرة دولية لنفس التركيبة · Novo Nordisk (novo-pi.com)
• Temporarily discontinue before iodinated contrast studies and surgical procedures; metformin may lower vitamin B12 levels.نشرة دولية لنفس التركيبة · Novo Nordisk (novo-pi.com)

• GemfibrozilContraindicated: markedly increases repaglinide exposure (about 8-fold AUC), more with itraconazole.Novo Nordisk (novo-pi.com)
• Cationic drugs eliminated by renal tubular secretionMay interfere with metformin elimination; use with caution.Novo Nordisk (novo-pi.com)

• No adequate and well-controlled studies in pregnant women; use during pregnancy only if clearly needed (US PrandiMet label, pregnancy category C).نشرة دولية لنفس التركيبة · Novo Nordisk (novo-pi.com)
• No lactation studies of the combination; both components are excreted into rat milk.نشرة دولية لنفس التركيبة · Novo Nordisk (novo-pi.com)

• Assess renal function before initiation and at least annually; measure hematological parameters (vitamin B12) annually; monitor blood glucose.نشرة دولية لنفس التركيبة · Novo Nordisk (novo-pi.com)

• ريباجلينيد: Stimulates insulin release from pancreatic beta cells (short-acting).
• ميتفورمين: Decreases hepatic glucose production and intestinal glucose absorption and improves insulin sensitivity.