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دواعي استعمال رستولام 0.5مجم 20 قرص

معلومات من نشرات دوائية ومراجع موثقة، مع مصدر كل معلومة. السعر الحالي: 24ج.م.

دواعي الاستعمال
  • Acute treatment of generalized anxiety disorder (GAD) in adults.الفئة: AdultsDailyMed (U.S. National Library of Medicine)
  • Treatment of panic disorder, with or without agoraphobia, in adults.الفئة: AdultsDailyMed (U.S. National Library of Medicine)
الآثار الجانبية
  • Post-marketing reports include hyperprolactinemia, peripheral edema, hepatitis/hepatic failure, liver enzyme elevations, hypomania/mania, gynecomastia, galactorrhea, photosensitivity, angioedema and Stevens-Johnson syndrome.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
موانع الاستعمال
  • Known hypersensitivity to alprazolam or other benzodiazepines (angioedema reported).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Concomitant use of strong CYP3A inhibitors (e.g. ketoconazole, itraconazole), except ritonavir.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
تحذيرات واحتياطات
  • Boxed warning: concomitant use with opioids may cause profound sedation, respiratory depression, coma and death.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Boxed warning: risk of abuse, misuse and addiction, which can lead to overdose or death.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Boxed warning: physical dependence; abrupt discontinuation or rapid dose reduction may cause life-threatening withdrawal reactions including seizures.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • CNS depression: caution against driving, operating machinery and use of alcohol.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Benzodiazepines may worsen depression; hypomania and mania have been reported in patients with depression.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Reports of death in patients with severe pulmonary disease shortly after starting treatment; monitor patients with impaired respiratory function.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
التداخلات الدوائية
  • OpioidsIncreased risk of respiratory depression, sedation, coma and death; limit dosage and duration of concomitant use.DailyMed (U.S. National Library of Medicine)
  • Strong CYP3A inhibitors (e.g. ketoconazole, itraconazole)Profoundly reduced alprazolam clearance; concomitant use contraindicated (except ritonavir).DailyMed (U.S. National Library of Medicine)
  • RitonavirReduce alprazolam to half the recommended dose when starting together; return to target dose after 10-14 days.DailyMed (U.S. National Library of Medicine)
  • Alcohol and other CNS depressantsAdditive CNS depression.DailyMed (U.S. National Library of Medicine)
الحمل والرضاعة
  • Observational data do not report a clear association between benzodiazepines and major birth defects.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Alprazolam is present in breast milk; sedation and poor feeding reported in exposed infants; breastfeeding is not recommended during treatment.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
المتابعة أثناء العلاج
  • Assess risk of abuse, misuse and addiction before and throughout treatment; frequently reassess the need for continued treatment.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Monitor neonates exposed during pregnancy or labour for sedation, respiratory depression, hypotonia, feeding problems and withdrawal.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
كيف يعمل الدواء
  • Binds the benzodiazepine site of GABA-A receptors and enhances GABA-mediated synaptic inhibition (US label).
سعر رستولام 0.5مجم 20 قرصالمثائل والبدائل

المصادر