دواعي استعمال ريفيا 50 مجم 30 قرص

Naltrexone 50 mg scored film-coated tablets, pack of 30.

• Treatment of alcohol dependenceالفئة: AdultsDailyMed (U.S. National Library of Medicine)
• Blockade of the effects of exogenously administered opioidsالفئة: AdultsDailyMed (U.S. National Library of Medicine)

• In alcohol-dependence trials (50 mg daily) the drug was generally well tolerated; nausea led to discontinuation in some patients. Higher doses (up to 300 mg/day) caused hepatocellular injury in a substantial proportion of patients.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Patients receiving opioid analgesics, currently opioid dependent (including methadone or buprenorphine maintenance), in acute opioid withdrawal, failing the naloxone challenge or with a positive opioid urine screen, or with hypersensitivity to naltrexone.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Vulnerability to opioid overdose: after treatment patients may respond to lower opioid doses; attempts to overcome blockade or use after stopping can cause fatal overdose.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Hepatotoxicity: cases of hepatitis and clinically significant liver dysfunction, and transient transaminase elevations, have been observed.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Opioid-containing medicines (analgesics, cough/cold, antidiarrhoeals)Patients may not benefit from opioid-containing medicines; emergency opioid analgesia may need higher doses with deeper, longer respiratory depression.DailyMed (U.S. National Library of Medicine)
• ThioridazineLethargy and somnolence reported with the combination.DailyMed (U.S. National Library of Medicine)
• DisulfiramSafety of combination unknown; concomitant use of two potentially hepatotoxic drugs not ordinarily recommended.DailyMed (U.S. National Library of Medicine)

• Increased early fetal loss in rats and rabbits at high doses, no teratogenicity at up to 200 mg/kg/day; no adequate human studies; use only if potential benefit justifies risk.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)