دواعي استعمال Rheumaton 750mg 10 f.c.tab.

Rheumaton 750 mg film-coated tablets, pack of 10 (Marcyrl Pharmaceutical Industries, Egypt): nabumetone, a non-steroidal anti-inflammatory prodrug.

• Relief of signs and symptoms of osteoarthritis and rheumatoid arthritis.الفئة: AdultsDailyMed (U.S. National Library of Medicine)

• Most frequent: diarrhea (14%), dyspepsia (13%), abdominal pain (12%); also constipation, flatulence, nausea, dizziness, headache, pruritus, rash, tinnitus and edema (3-9%).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to nabumetone or excipients; asthma, urticaria or allergic-type reactions after aspirin or other NSAIDs; setting of coronary artery bypass graft (CABG) surgery.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Boxed warning: NSAIDs increase the risk of serious cardiovascular thrombotic events (myocardial infarction, stroke), which can be fatal and may occur early in treatment.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Boxed warning: NSAIDs increase the risk of serious gastrointestinal bleeding, ulceration and perforation, which can be fatal and occur without warning; elderly patients are at greater risk.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• ACE inhibitorsNSAIDs may diminish the antihypertensive effect of ACE inhibitors.DailyMed (U.S. National Library of Medicine)
• Diuretics (furosemide, thiazides)Nabumetone can reduce the natriuretic effect; observe for renal failure and diuretic efficacy.DailyMed (U.S. National Library of Medicine)
• LithiumNSAIDs raise plasma lithium levels and reduce renal lithium clearance.DailyMed (U.S. National Library of Medicine)
• AspirinConcomitant use is not generally recommended because of potential increased adverse effects.DailyMed (U.S. National Library of Medicine)

• NSAID use can cause premature closure of the fetal ductus arteriosus and fetal renal dysfunction leading to oligohydramnios; limit dose and duration between about 20 and 30 weeks of gestation and avoid at about 30 weeks and later.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• In moderate or severe renal insufficiency, monitor renal function carefully before increasing the dose.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Prodrug converted in the liver to 6-methoxy-2-naphthylacetic acid (6MNA), a potent inhibitor of prostaglandin synthesis (US label).