دواعي استعمال ريبافارين 200مجم 12 كبسولة

Ribavirin 200 mg oral capsules (nucleoside analogue antiviral), used in combination regimens for chronic hepatitis C.

• Treatment of chronic hepatitis C with compensated liver disease, in combination with interferon alfa-2b (pegylated or non-pegylated), in patients 3 years and older; not effective as monotherapy.الفئة: Patients >=3 yearsDailyMed (U.S. National Library of Medicine)

• Contraindicated in pregnancy, in women planning pregnancy, and in men whose female partners are pregnant.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Also contraindicated in autoimmune hepatitis, hemoglobinopathies (e.g. thalassemia major, sickle-cell anemia), creatinine clearance below 50 mL/min, prior severe skin hypersensitivity (SJS/TEN/erythema multiforme) to ribavirin, and with didanosine.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Boxed warning: significant teratogenic and embryocidal effects in animals; avoid pregnancy and use effective contraception during therapy and for 9 months after (female patients) or 6 months after (female partners of male patients).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Boxed warning: hemolytic anemia (about 10% with ribavirin/interferon alfa-2b) usually within 1-2 weeks of starting, which may worsen cardiac disease; ribavirin monotherapy is not effective for chronic hepatitis C.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• DidanosineRibavirin increases exposure to didanosine or its active metabolite, with fatal hepatic failure, peripheral neuropathy, pancreatitis and lactic acidosis reported; coadministration is contraindicated.DailyMed (U.S. National Library of Medicine)

• Contraindicated in pregnant women and in men whose partners are pregnant; animal data show teratogenic and/or embryocidal effects and ribavirin persists in non-plasma compartments for up to 6 months.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• No data on ribavirin in human milk or effects on the breastfed infant; weigh benefits of breastfeeding against the mother's need for therapy.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Obtain hemoglobin/hematocrit before treatment and at weeks 2 and 4, plus complete blood counts, liver function tests and TSH before and periodically during therapy.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Exact antiviral mechanism not fully understood; has direct activity against many RNA viruses, increases viral mutation frequency, and ribavirin triphosphate inhibits HCV polymerase in vitro.