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دواعي استعمال ريبوفينال 200مجم 21 شريط في 8 كبسول

معلومات من نشرات دوائية ومراجع موثقة، مع مصدر كل معلومة. السعر الحالي: 252ج.م.

دواعي الاستعمال
  • In combination with interferon alfa-2b (pegylated or non-pegylated) for chronic hepatitis C in patients 3 years and older with compensated liver disease; ribavirin monotherapy is not effective for CHC.DailyMed (U.S. National Library of Medicine)
الآثار الجانبية
  • Hemolytic anemia occurred in more than 10% of adults receiving ribavirin with peginterferon/interferon alfa-2b.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Most common adverse reactions (40% or more) in adults on combination therapy: injection site reaction, fatigue/asthenia, headache, rigors, fever, nausea, myalgia and anxiety/emotional lability/irritability.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
موانع الاستعمال
  • Pregnancy; ribavirin may cause fetal harm and is contraindicated in women who are pregnant or planning pregnancy.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Men whose female partners are pregnant.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Known hypersensitivity reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis or erythema multiforme to ribavirin or any component.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Autoimmune hepatitis.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Hemoglobinopathies (e.g. thalassemia major, sickle-cell anemia).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Creatinine clearance less than 50 mL/min.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Coadministration with didanosine.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
تحذيرات واحتياطات
  • Boxed warning - embryo-fetal toxicity: significant teratogenic/embryocidal effects in all animal species; avoid pregnancy and use effective contraception during therapy and for 9 months after treatment in female patients and for 6 months in female partners of male patients.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Boxed warning - hemolytic anemia, which may worsen cardiac disease and has led to fatal and nonfatal myocardial infarction; patients with significant or unstable cardiac disease should not be treated.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Ribavirin monotherapy is not effective for chronic hepatitis C and should not be used alone for this indication.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Other label warnings include pancreatitis, pulmonary disorders, ophthalmologic disorders, dental/periodontal disorders, azathioprine coadministration and impact on growth in pediatric patients.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
التداخلات الدوائية
  • DidanosineIncreased exposure to didanosine active metabolite; fatal hepatic failure, peripheral neuropathy, pancreatitis and lactic acidosis reported; coadministration contraindicated.DailyMed (U.S. National Library of Medicine)
  • Nucleoside reverse transcriptase inhibitorsHepatic decompensation (some fatal) in cirrhotic HIV/HCV co-infected patients; monitor closely for toxicities including anemia.DailyMed (U.S. National Library of Medicine)
  • AzathioprineSevere pancytopenia reported; ribavirin inhibits IMPDH and may increase azathioprine-related myelotoxicity.DailyMed (U.S. National Library of Medicine)
الحمل والرضاعة
  • Contraindicated in pregnant women and in men whose female partners are pregnant; animal data show teratogenic and/or embryocidal effects, and Ribavirin Pregnancy Registry data showed higher birth-defect rates than background.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • No data on presence of ribavirin in human milk or effects on the breastfed infant; weigh benefits of breastfeeding against maternal need and potential infant risk.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
المتابعة أثناء العلاج
  • Obtain hemoglobin or hematocrit before treatment and at weeks 2 and 4 of therapy, or more often if clinically indicated.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Negative pregnancy test required immediately before starting therapy, with periodic pregnancy tests during treatment and for 9 months after.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
كيف يعمل الدواء
  • Nucleoside (guanosine) analogue antiviral; per the US label the mechanism by which ribavirin contributes to antiviral efficacy against HCV is not fully understood.
سعر ريبوفينال 200مجم 21 شريط في 8 كبسولالمثائل والبدائل

المصادر