دواعي استعمال ريفامبيسين 150مجم 8 كبسول

معلومات من نشرات دوائية ومراجع موثقة، مع مصدر كل معلومة. السعر الحالي: 6.45ج.م.

دواعي الاستعمال

Treatment of all forms of tuberculosis, as part of a multidrug regimen (e.g. with isoniazid and pyrazinamide in the initial phase).DailyMed (U.S. National Library of Medicine)
Asymptomatic carriers of Neisseria meningitidis, to eliminate meningococci from the nasopharynx (not for treatment of meningococcal infection).DailyMed (U.S. National Library of Medicine)

الآثار الجانبية

Gastrointestinal effects (heartburn, epigastric distress, anorexia, nausea, vomiting, flatulence, cramps, diarrhoea); pseudomembranous colitis reported.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Hepatic (transient LFT abnormalities, hepatitis), haematologic (thrombocytopenia, leukopenia, haemolytic anaemia), CNS (headache, drowsiness, dizziness, fatigue), flushing/itching and hypersensitivity reactions.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

موانع الاستعمال

Hypersensitivity to rifampin, any component, or any rifamycin.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Concomitant ritonavir-boosted saquinavir (severe hepatocellular toxicity).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Concomitant atazanavir, darunavir, fosamprenavir, saquinavir, tipranavir, cabotegravir, fostemsavir or lenacapavir (loss of antiviral efficacy).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Concomitant praziquantel.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Concomitant lurasidone.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

تحذيرات واحتياطات

Hepatotoxicity (hepatocellular, cholestatic or mixed), ranging up to fulminant liver failure and death; in hepatic impairment use only when necessary with liver monitoring every 2-4 weeks.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Systemic hypersensitivity reactions and severe cutaneous adverse reactions (SJS, TEN, AGEP, DRESS); discontinue if they occur.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Vitamin K-dependent coagulation disorders and bleeding; avoid high-dose cefazolin co-use in patients at bleeding risk.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Pulmonary toxicity (interstitial lung disease), thrombotic microangiopathy, porphyria exacerbation and paradoxical drug reactions have been reported.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

التداخلات الدوائية

Drugs metabolised by CYP1A2, 2B6, 2C8, 2C9, 2C19, 3A4, UGT or transported by P-gp/MRP2Rifampin induces these enzymes/transporters and may decrease concentrations and effect of many co-administered drugs; adjust doses per their labeling.DailyMed (U.S. National Library of Medicine)
Isoniazid / halothane / other hepatotoxic drugsIncreased potential for hepatotoxicity; avoid halothane and monitor closely with isoniazid.DailyMed (U.S. National Library of Medicine)

الحمل والرضاعة

No adequate well-controlled studies in pregnant women; rifampin crosses the placenta; decades of data have not established an association with major birth defects; use only if benefit outweighs risk.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Because of tumorigenicity potential in animal studies, decide whether to discontinue nursing or the drug.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

المتابعة أثناء العلاج

Monitor for liver injury; in hepatic impairment check liver function before therapy and every 2-4 weeks; obtain cultures/susceptibility before and during therapy.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

كيف يعمل الدواء

المصادر