دواعي استعمال رايت-إيس 5 مجم أقراص

Ramipril 5 mg oral tablets (ACE inhibitor), pack of 30, marketed in Egypt by Adwia.

• Treatment of hypertensionالفئة: Adultselectronic medicines compendium (emc)
• Cardiovascular prevention: reduction of cardiovascular morbidity and mortality in patients with manifest atherothrombotic cardiovascular disease or diabetes with at least one cardiovascular risk factorالفئة: Adultselectronic medicines compendium (emc)
• Treatment of renal disease (incipient or manifest diabetic glomerular nephropathy; manifest non-diabetic glomerular nephropathy)الفئة: Adultselectronic medicines compendium (emc)

• Most common adverse reactions in hypertension trials: headache, dizziness, fatigue and cough.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)
• Common: headache, dizziness and increased blood potassium (among others listed in the SmPC frequency table).نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)

• Hypersensitivity to ramipril, any excipient or any other ACE inhibitor.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• History of angioedema (hereditary, idiopathic or due to previous ACE inhibitor or AIIRA angioedema).نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Significant bilateral renal artery stenosis or renal artery stenosis in a single functioning kidney; hypotensive or haemodynamically unstable states; extracorporeal treatments bringing blood into contact with negatively charged surfaces.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Second and third trimesters of pregnancy.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Concomitant aliskiren in patients with diabetes mellitus or renal impairment.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Do not combine with a neprilysin inhibitor (e.g. sacubitril); do not give within 36 hours of switching to or from sacubitril/valsartan.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)

• Boxed warning: fetal toxicity. Drugs acting directly on the renin-angiotensin system can cause injury and death to the developing fetus; discontinue as soon as pregnancy is detected.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)
• Angioedema (including intestinal angioedema) and anaphylactoid reactions may occur at any time during ACE inhibitor treatment.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)
• Symptomatic hypotension, most likely in volume- or salt-depleted patients (e.g. on prolonged diuretic therapy).معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)
• Hyperkalaemia, renal function deterioration in susceptible patients, rare cholestatic jaundice progressing to hepatic necrosis, and rare neutropenia/agranulocytosis have been reported with ACE inhibitors.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)
• Persistent non-productive cough can occur with all ACE inhibitors and resolves after discontinuation.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)

• DiureticsExcessive blood pressure reduction may occur after starting ramipril in patients on diuretics.DailyMed (U.S. National Library of Medicine)
• Potassium-raising agents (potassium supplements, potassium-sparing diuretics)May cause hyperkalaemia; monitor serum potassium.DailyMed (U.S. National Library of Medicine)
• LithiumIncreased serum lithium and lithium toxicity reported; monitor lithium levels.DailyMed (U.S. National Library of Medicine)
• NSAIDs including COX-2 inhibitorsIn elderly, volume-depleted or renally impaired patients, may worsen renal function including acute renal failure.DailyMed (U.S. National Library of Medicine)
• Aliskiren, ARBs, other RAS inhibitorsDual RAS blockade increases risk of hypotension, hyperkalaemia and renal function changes; avoid; aliskiren contraindicated in diabetes.DailyMed (U.S. National Library of Medicine)
• mTOR inhibitors (e.g. temsirolimus) or neprilysin inhibitorsIncreased risk of angioedema.DailyMed (U.S. National Library of Medicine)

• Use of renin-angiotensin system drugs in the second and third trimesters reduces fetal renal function and increases fetal and neonatal morbidity and death; discontinue as soon as pregnancy is detected.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)

• Establish baseline renal function; monitor serum potassium when combined with potassium-raising drugs and lithium levels when combined with lithium.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)

• Prodrug hydrolysed to ramiprilat, which inhibits angiotensin-converting enzyme, reducing angiotensin II formation and aldosterone secretion.