دواعي استعمال ريمكتان 300مجم 8 كبسولات

Rimactane 300 mg capsules (rifampicin 300 mg, pack of 8) by Novartis, an Egyptian oral rifampicin antituberculosis antibiotic.

• Treatment of asymptomatic carriers of Neisseria meningitidis to eliminate meningococci from the nasopharynx (not for treatment of meningococcal infection).DailyMed (U.S. National Library of Medicine)
• Treatment of all forms of tuberculosis, in combination with other antituberculosis drugs.DailyMed (U.S. National Library of Medicine)

• Gastrointestinal: heartburn, epigastric distress, anorexia, nausea, vomiting, jaundice, flatulence, cramps, diarrhoea; pseudomembranous colitis reported.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Thrombocytopenia with or without purpura (mainly with intermittent therapy), flu-like reactions, hepatitis and hyperbilirubinaemia, and severe skin reactions (SJS, TEN, DRESS, AGEP).معلومة عامة عن المادة الفعالة · electronic medicines compendium (emc)

• Hypersensitivity to rifamycins or any excipient.معلومة عامة عن المادة الفعالة · electronic medicines compendium (emc)
• Jaundice.معلومة عامة عن المادة الفعالة · electronic medicines compendium (emc)
• Concurrent saquinavir/ritonavir.معلومة عامة عن المادة الفعالة · electronic medicines compendium (emc)
• Medicines strongly affected by enzyme/transporter induction: lurasidone, sofosbuvir, daclatasvir, telaprevir, cabotegravir, fostemsavir, lenacapavir.معلومة عامة عن المادة الفعالة · electronic medicines compendium (emc)
• Concurrent atazanavir, darunavir, fosamprenavir, saquinavir, tipranavir, or praziquantel.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Hepatotoxicity ranging from asymptomatic enzyme rises to fulminant liver failure and death; monitor liver function, especially with liver disease or other hepatotoxic drugs, and discontinue if hepatic damage occurs or worsens.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Possible immunological reactions including anaphylaxis with intermittent therapy; patients should not interrupt dosing.معلومة عامة عن المادة الفعالة · electronic medicines compendium (emc)
• Discolours urine, sweat, sputum, tears and teeth (yellow, orange, red or brown); soft contact lenses may be permanently stained.معلومة عامة عن المادة الفعالة · electronic medicines compendium (emc)
• Potent inducer of drug-metabolising enzymes and transporters; consider interactions when starting or stopping rifampicin.معلومة عامة عن المادة الفعالة · electronic medicines compendium (emc)
• Vitamin K-dependent coagulopathy and bleeding: monitor coagulation tests in patients at risk; consider vitamin K.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Interstitial lung disease/pneumonitis can occur and may be fatal; discontinue if severe pulmonary toxicity develops.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Hormonal contraceptivesRifampicin reduces contraceptive exposure; change to non-hormonal contraception.electronic medicines compendium (emc)
• AntacidsMay reduce rifampicin absorption; give rifampicin at least 1 hour before antacids.electronic medicines compendium (emc)
• CYP3A4/CYP2C/UGT/P-gp substrates (e.g. warfarin, ciclosporin, tacrolimus, azole antifungals, many antiretrovirals)Induction lowers their plasma levels and effect; dose adjustment or avoidance may be needed.electronic medicines compendium (emc)
• Halothane / isoniazidIncreased potential for hepatotoxicity; avoid halothane and monitor closely with isoniazid.electronic medicines compendium (emc)

• Teratogenic in animals at very high doses; no well-controlled human studies. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus.معلومة عامة عن المادة الفعالة · electronic medicines compendium (emc)
• Published data over decades of use have not established an association with major birth defects or miscarriage; teratogenic in rodents.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Rifampicin is excreted in breast milk; patients should not breast-feed unless the physician judges the benefit outweighs the risk to the infant.معلومة عامة عن المادة الفعالة · electronic medicines compendium (emc)

• Baseline liver function tests for all tuberculosis patients; adults should also have baseline hepatic enzymes, bilirubin, serum creatinine, complete blood count and platelet count.معلومة عامة عن المادة الفعالة · electronic medicines compendium (emc)

• Inhibits bacterial DNA-dependent RNA polymerase without affecting the mammalian enzyme.