دواعي استعمال ريتوكسيرا 100 مجم/10 مل

Rituxera (rituximab) 100 mg/10 mL concentrate for IV infusion, 2 vials x 10 mL; listed in Egypt under F. Hoffmann-La Roche with Memphis.

• Non-Hodgkin's lymphoma (CD20-positive B-cell NHL).DailyMed (NLM)
• Chronic lymphocytic leukemia (with fludarabine and cyclophosphamide).DailyMed (NLM)
• Rheumatoid arthritis (with methotrexate).DailyMed (NLM)
• Granulomatosis with polyangiitis and microscopic polyangiitis.DailyMed (NLM)
• Pemphigus vulgaris.DailyMed (NLM)

• The US label lists no contraindications.نشرة دولية لنفس التركيبة · DailyMed (NLM)

• Boxed warning: fatal infusion-related reactions (mostly within 24 h of the first infusion), severe mucocutaneous reactions, hepatitis B virus reactivation and progressive multifocal leukoencephalopathy.نشرة دولية لنفس التركيبة · DailyMed (NLM)
• Other warnings: tumor lysis syndrome, serious infections, cardiac arrhythmias, renal toxicity, bowel obstruction/perforation; avoid live vaccines; embryo-fetal toxicity.نشرة دولية لنفس التركيبة · DailyMed (NLM)

• Can cause adverse developmental outcomes including B-cell lymphocytopenia in infants exposed in utero; advise pregnant women of fetal risk.نشرة دولية لنفس التركيبة · DailyMed (NLM)
• Advise not to breastfeed during treatment and for 6 months after the last dose.نشرة دولية لنفس التركيبة · DailyMed (NLM)

• Screen all patients for HBV infection (HBsAg and anti-HBc) before starting; monitor during infusion for reactions.نشرة دولية لنفس التركيبة · DailyMed (NLM)