تخطَّ إلى المحتوى
دليل الأدوية المصري
تابع آخر تحديثات الأسعار على واتساب

دواعي استعمال ريفاكسيل 1.5مجم 28 كبسولة

معلومات من نشرات دوائية ومراجع موثقة، مع مصدر كل معلومة. السعر الحالي: 52ج.م.

دواعي الاستعمال
  • Treatment of mild-to-moderate dementia of the Alzheimer's typeالفئة: AdultsDailyMed (U.S. National Library of Medicine)
  • Treatment of mild-to-moderate dementia associated with Parkinson's diseaseالفئة: AdultsDailyMed (U.S. National Library of Medicine)
  • Symptomatic treatment of mild to moderately severe Alzheimer's dementiaالفئة: AdultsEuropean Medicines Agency
  • Symptomatic treatment of mild to moderately severe dementia in patients with idiopathic Parkinson's diseaseالفئة: AdultsEuropean Medicines Agency
الآثار الجانبية
  • Most common adverse reactions (at least 5% and twice placebo): nausea, vomiting, anorexia, dyspepsia and asthenia.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Most commonly reported adverse reactions are gastrointestinal, including nausea (38%) and vomiting (23%), especially during titration; women are more susceptible to GI reactions and weight loss.نشرة دولية لنفس التركيبة · European Medicines Agency
موانع الاستعمال
  • Known hypersensitivity to rivastigmine, other carbamate derivatives or other components of the formulation.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Previous history of application-site reaction with rivastigmine transdermal patch suggestive of allergic contact dermatitis, in the absence of negative allergy testing.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
تحذيرات واحتياطات
  • Gastrointestinal adverse reactions (significant nausea, vomiting, diarrhoea, anorexia, weight loss) are dose-related; dehydration from prolonged vomiting or diarrhoea can be serious. Always start at 1.5 mg twice daily and titrate.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Disseminated allergic dermatitis has been reported with oral or transdermal rivastigmine; discontinue if it occurs.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Cholinomimetic effects: may induce or worsen extrapyramidal symptoms (worsening tremor in Parkinson's disease dementia), may cause seizures, may increase gastric acid secretion (monitor for GI bleeding, especially with ulcer history or NSAIDs), may exaggerate succinylcholine-type muscle relaxation during anaesthesia, and may have vagotonic effects on heart rate.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Dementia and rivastigmine adverse reactions may impair driving or operating machinery; evaluate routinely.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • QT prolongation and bradycardia (a risk factor for torsade de pointes) may occur; caution in patients with QTc prolongation risk, sick sinus syndrome or conduction defects; ECG monitoring may be required.نشرة دولية لنفس التركيبة · European Medicines Agency
  • Caution in active gastric or duodenal ulcers, asthma or obstructive pulmonary disease, urinary obstruction and seizure predisposition; monitor body weight during therapy.نشرة دولية لنفس التركيبة · European Medicines Agency
التداخلات الدوائية
  • MetoclopramideConcomitant use not recommended because of additive extrapyramidal adverse reactions.DailyMed (U.S. National Library of Medicine)
  • Cholinomimetic and anticholinergic medicines (e.g. oxybutynin, tolterodine)Rivastigmine may increase cholinergic effects of cholinomimetics and interfere with anticholinergics; avoid unless clinically necessary.DailyMed (U.S. National Library of Medicine)
  • Beta-blockers (especially cardioselective, e.g. atenolol)Additive bradycardic effects resulting in syncope may occur; concomitant use not recommended.DailyMed (U.S. National Library of Medicine)
  • QT-prolonging or bradycardic agents (e.g. class III antiarrhythmics, calcium channel antagonists, digitalis, some antipsychotics)Use with caution and clinical (ECG) monitoring because bradycardia is a risk factor for torsades de pointes.European Medicines Agency
الحمل والرضاعة
  • No adequate data in pregnant women; no adverse embryo-fetal effects in rats and rabbits at 2-4 times the maximum recommended human dose.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • No clinical data on exposed pregnancies; should not be used during pregnancy unless clearly necessary.نشرة دولية لنفس التركيبة · European Medicines Agency
  • No data on presence in human milk; rivastigmine and metabolites are excreted in rat milk. Weigh benefits of breastfeeding against the mother's need and potential infant effects.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Rivastigmine is excreted in animal milk; women on rivastigmine should not breast-feed.نشرة دولية لنفس التركيبة · European Medicines Agency
المتابعة أثناء العلاج
  • Monitor body weight during therapy; clinical monitoring for extrapyramidal worsening; ECG monitoring may be required in patients at risk of QT prolongation.نشرة دولية لنفس التركيبة · European Medicines Agency
كيف يعمل الدواء
  • Reversible cholinesterase inhibitor; thought to enhance cholinergic function by increasing acetylcholine concentration through inhibition of its hydrolysis (US label 12.1).
سعر ريفاكسيل 1.5مجم 28 كبسولةالمثائل والبدائل

المصادر