سعر ريفاكسيل 6مجم 7 كبسولات 2022
Rivaxel 6 mg- المادة الفعالة: Rivastigmine
- Hikma Pharma
- عن طريق الفم
الفئة: مضاد للخرف
معلومات الدواء
التفاصيل الكاملةدواعي الاستعمالUses
- Treatment of mild-to-moderate dementia of the Alzheimer's typeالفئة: AdultsDailyMed (U.S. National Library of Medicine)
- Treatment of mild-to-moderate dementia associated with Parkinson's diseaseالفئة: AdultsDailyMed (U.S. National Library of Medicine)
- Symptomatic treatment of mild to moderately severe Alzheimer's dementiaالفئة: AdultsEuropean Medicines Agency
- Treatment of mild-to-moderate dementia of the Alzheimer's typePopulation: AdultsDailyMed (U.S. National Library of Medicine)
- Treatment of mild-to-moderate dementia associated with Parkinson's diseasePopulation: AdultsDailyMed (U.S. National Library of Medicine)
- Symptomatic treatment of mild to moderately severe Alzheimer's dementiaPopulation: AdultsEuropean Medicines Agency
الآثار الجانبيةSide effects
- Most common adverse reactions (at least 5% and twice placebo): nausea, vomiting, anorexia, dyspepsia and asthenia.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
- Most commonly reported adverse reactions are gastrointestinal, including nausea (38%) and vomiting (23%), especially during titration; women are more susceptible to GI reactions and weight loss.نشرة دولية لنفس التركيبة · European Medicines Agency
- Most common adverse reactions (at least 5% and twice placebo): nausea, vomiting, anorexia, dyspepsia and asthenia.International label, same formulation · DailyMed (U.S. National Library of Medicine)
- Most commonly reported adverse reactions are gastrointestinal, including nausea (38%) and vomiting (23%), especially during titration; women are more susceptible to GI reactions and weight loss.International label, same formulation · European Medicines Agency
موانع الاستعمالContraindications
- Known hypersensitivity to rivastigmine, other carbamate derivatives or other components of the formulation.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
- Previous history of application-site reaction with rivastigmine transdermal patch suggestive of allergic contact dermatitis, in the absence of negative allergy testing.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
- Known hypersensitivity to rivastigmine, other carbamate derivatives or other components of the formulation.International label, same formulation · DailyMed (U.S. National Library of Medicine)
- Previous history of application-site reaction with rivastigmine transdermal patch suggestive of allergic contact dermatitis, in the absence of negative allergy testing.International label, same formulation · DailyMed (U.S. National Library of Medicine)
تحذيرات واحتياطاتWarnings & precautions
- Gastrointestinal adverse reactions (significant nausea, vomiting, diarrhoea, anorexia, weight loss) are dose-related; dehydration from prolonged vomiting or diarrhoea can be serious. Always start at 1.5 mg twice daily and titrate.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
- Disseminated allergic dermatitis has been reported with oral or transdermal rivastigmine; discontinue if it occurs.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
- Cholinomimetic effects: may induce or worsen extrapyramidal symptoms (worsening tremor in Parkinson's disease dementia), may cause seizures, may increase gastric acid secretion (monitor for GI bleeding, especially with ulcer history or NSAIDs), may exaggerate succinylcholine-type muscle relaxation during anaesthesia, and may have vagotonic effects on heart rate.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
- Gastrointestinal adverse reactions (significant nausea, vomiting, diarrhoea, anorexia, weight loss) are dose-related; dehydration from prolonged vomiting or diarrhoea can be serious. Always start at 1.5 mg twice daily and titrate.International label, same formulation · DailyMed (U.S. National Library of Medicine)
- Disseminated allergic dermatitis has been reported with oral or transdermal rivastigmine; discontinue if it occurs.International label, same formulation · DailyMed (U.S. National Library of Medicine)
- Cholinomimetic effects: may induce or worsen extrapyramidal symptoms (worsening tremor in Parkinson's disease dementia), may cause seizures, may increase gastric acid secretion (monitor for GI bleeding, especially with ulcer history or NSAIDs), may exaggerate succinylcholine-type muscle relaxation during anaesthesia, and may have vagotonic effects on heart rate.International label, same formulation · DailyMed (U.S. National Library of Medicine)
التداخلات الدوائيةDrug interactions
- MetoclopramideConcomitant use not recommended because of additive extrapyramidal adverse reactions.DailyMed (U.S. National Library of Medicine)
- Cholinomimetic and anticholinergic medicines (e.g. oxybutynin, tolterodine)Rivastigmine may increase cholinergic effects of cholinomimetics and interfere with anticholinergics; avoid unless clinically necessary.DailyMed (U.S. National Library of Medicine)
- Beta-blockers (especially cardioselective, e.g. atenolol)Additive bradycardic effects resulting in syncope may occur; concomitant use not recommended.DailyMed (U.S. National Library of Medicine)
- MetoclopramideConcomitant use not recommended because of additive extrapyramidal adverse reactions.DailyMed (U.S. National Library of Medicine)
- Cholinomimetic and anticholinergic medicines (e.g. oxybutynin, tolterodine)Rivastigmine may increase cholinergic effects of cholinomimetics and interfere with anticholinergics; avoid unless clinically necessary.DailyMed (U.S. National Library of Medicine)
- Beta-blockers (especially cardioselective, e.g. atenolol)Additive bradycardic effects resulting in syncope may occur; concomitant use not recommended.DailyMed (U.S. National Library of Medicine)
الحمل والرضاعةPregnancy & breastfeeding
- No adequate data in pregnant women; no adverse embryo-fetal effects in rats and rabbits at 2-4 times the maximum recommended human dose.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
- No clinical data on exposed pregnancies; should not be used during pregnancy unless clearly necessary.نشرة دولية لنفس التركيبة · European Medicines Agency
- No data on presence in human milk; rivastigmine and metabolites are excreted in rat milk. Weigh benefits of breastfeeding against the mother's need and potential infant effects.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
- No adequate data in pregnant women; no adverse embryo-fetal effects in rats and rabbits at 2-4 times the maximum recommended human dose.International label, same formulation · DailyMed (U.S. National Library of Medicine)
- No clinical data on exposed pregnancies; should not be used during pregnancy unless clearly necessary.International label, same formulation · European Medicines Agency
- No data on presence in human milk; rivastigmine and metabolites are excreted in rat milk. Weigh benefits of breastfeeding against the mother's need and potential infant effects.International label, same formulation · DailyMed (U.S. National Library of Medicine)
كيف يعمل الدواءHow it works
- Reversible cholinesterase inhibitor; thought to enhance cholinergic function by increasing acetylcholine concentration through inhibition of its hydrolysis (US label 12.1).
- Rivastigmine: Reversible cholinesterase inhibitor; thought to enhance cholinergic function by increasing acetylcholine concentration through inhibition of its hydrolysis (US label 12.1).
المثائل (4)
كل المثائل والبدائلنفس المادة الفعالة والتركيز. اسأل الصيدلي قبل الاستبدال.
| الدواء | السعر | الفرق عن الأصلي |
|---|---|---|
| ريفاميب 6مجم 20 كبسولاتRivamep 6 mgMepaco · 6 mgالأرخص | السعر60ج.م3ج.م للوحدة | الفرق عن الأصليأغلى 30ج.م (100%) |
| اكسيلون 6 مجم 14 كبسولةExelon 6 mg 14 caps.Novartis · كبسولات صلبة · 6 mg | السعر105ج.م7.5ج.م للوحدة | الفرق عن الأصليأغلى 75ج.م (250%) |
| ريفاماشRivamash 6 mgMash Premiere · 6 mg | السعر246ج.م8.2ج.م للوحدة | الفرق عن الأصليأغلى 216ج.م (720%) |
| اكسيلون 6 مجم 28 كبسولةExelon 6mg 28 caps.Novartis · كبسولات صلبة · 6 mg | السعر350ج.م12.5ج.م للوحدة | الفرق عن الأصليأغلى 320ج.م (1,066.7%) |
أدوية ذات صلة
نفس المادة الفعالة بتركيز آخر
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المصادر
- السعر: قوائم أسعار الأدوية المنشورة في مصر.
- DailyMed (U.S. National Library of Medicine)
- European Medicines Agency
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