دواعي استعمال روكالترول 0.5 ميكروجرام 30 كبسولة

Calcitriol 0.5 microgram oral soft capsules (Roche brand) for disorders of calcium metabolism; 30 capsules (3 strips) per pack.

• Management of secondary hyperparathyroidism and metabolic bone disease in moderate to severe chronic renal failure (CrCl 15-55 mL/min) not yet on dialysis.DailyMed (U.S. National Library of Medicine)
• Management of hypocalcaemia and metabolic bone disease in patients on chronic renal dialysis.DailyMed (U.S. National Library of Medicine)
• Management of hypocalcaemia in postsurgical or idiopathic hypoparathyroidism and pseudohypoparathyroidism.DailyMed (U.S. National Library of Medicine)

• Hypercalcaemia or evidence of vitamin D toxicity.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity to calcitriol, drugs of the same class or any inactive ingredient.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Overdosage of vitamin D is dangerous; excess calcitriol causes hypercalcaemia, hypercalciuria and hyperphosphataemia; withhold pharmacological doses of other vitamin D during treatment.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Keep the serum calcium x phosphate product below 70 mg2/dL2; chronic hypercalcaemia can cause vascular calcification and nephrocalcinosis.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Thiazide diureticsMay cause hypercalcaemia when given with calcitriol; use with caution.DailyMed (U.S. National Library of Medicine)
• Digitalis glycosidesHypercalcaemia may precipitate cardiac arrhythmias; dose calcitriol carefully.DailyMed (U.S. National Library of Medicine)
• CholestyramineMay impair intestinal absorption of calcitriol.DailyMed (U.S. National Library of Medicine)
• Phenytoin / phenobarbitalMay lower endogenous 25(OH)D3; higher calcitriol doses may be needed.DailyMed (U.S. National Library of Medicine)

• Teratogenic in rabbits at multiples of the maximum human dose; no adequate studies in pregnant women; use only if the benefit justifies the risk to the fetus.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Calcitriol may be excreted in human milk; the US label advises that a mother should not nurse while taking calcitriol capsules.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Check serum calcium at least twice weekly during dose titration, then monthly once the optimal dose is established.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)