دواعي استعمال رولاكسيمين 550 مجم

Rolaximine rifaximin 550 mg film-coated tablets, pack of 30 (Eva Pharma / Horus, Egypt).

• Reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults.DailyMed (U.S. National Library of Medicine)
• Treatment of irritable bowel syndrome with diarrhoea (IBS-D) in adults.DailyMed (U.S. National Library of Medicine)
• Treatment of travellers' diarrhoea caused by noninvasive E. coli in patients 12 years and older (US label uses the 200 mg tablet for this indication).DailyMed (U.S. National Library of Medicine)

• HE (>=10%): peripheral oedema, nausea, constipation, dizziness, fatigue, urinary tract infection, insomnia, anaemia, pruritus, ascites. IBS-D (>=2%): ALT increased, nausea. TD (>=2%): headache.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to rifaximin, any rifamycin antimicrobial, or any component; reactions have included exfoliative dermatitis, angioneurotic oedema and anaphylaxis.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Not effective in diarrhoea complicated by fever and/or blood in stool or caused by pathogens other than E. coli (e.g. Campylobacter jejuni); discontinue if symptoms worsen or persist beyond 24-48 hours.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Clostridioides difficile-associated diarrhoea has been reported and may range from mild diarrhoea to fatal colitis.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Concomitant P-glycoprotein inhibitors (e.g. cyclosporine) can substantially increase systemic rifaximin exposure; use caution.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• P-glycoprotein inhibitors (e.g. cyclosporine)Cyclosporine increased rifaximin Cmax ~83-fold and AUC ~124-fold; caution with concomitant use.DailyMed (U.S. National Library of Medicine)
• WarfarinINR changes reported post-marketing; monitor INR/prothrombin time and adjust warfarin as needed.DailyMed (U.S. National Library of Medicine)

• No human data; teratogenic effects (ocular, oral/maxillofacial, cardiac, lumbar spine malformations) in rats and rabbits; may cause fetal harm; advise pregnant women of potential risk.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• No information on presence in human milk or effects on the breastfed infant or milk production; weigh benefits of breastfeeding against maternal need and potential infant risk.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Monitor INR and prothrombin time in patients on warfarin.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Binds the beta-subunit of bacterial DNA-dependent RNA polymerase, inhibiting bacterial RNA synthesis (directory pharmacology text; consistent with US label class).