دواعي استعمال Roqarik 90 mg 20 tabs

Etoricoxib 90 mg tablets, 20 per pack (2 strips), by HP Pharma (Egypt); selective COX-2 inhibitor NSAID.

• Symptomatic relief of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and pain and signs of inflammation associated with acute gouty arthritis.الفئة: Adults and adolescents 16 years and olderelectronic medicines compendium (emc)
• Short-term treatment of moderate pain associated with dental surgery.الفئة: Adults and adolescents 16 years and olderelectronic medicines compendium (emc)

• Common: alveolar osteitis, oedema/fluid retention, dizziness, headache, palpitations, arrhythmia, hypertension.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Uncommon to rare include hypersensitivity, angioedema/anaphylactic reactions, congestive heart failure, myocardial infarction, cerebrovascular accident, anaemia, thrombocytopenia.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)

• Hypersensitivity; active peptic ulceration or active GI bleeding; bronchospasm, acute rhinitis, nasal polyps, angioneurotic oedema, urticaria or allergic-type reactions after aspirin/NSAIDs including COX-2 inhibitors.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Pregnancy and lactation; severe hepatic dysfunction; CrCl <30 mL/min; children and adolescents under 16; inflammatory bowel disease.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Congestive heart failure (NYHA II-IV); uncontrolled hypertension persistently above 140/90 mmHg; established ischaemic heart disease, peripheral arterial disease and/or cerebrovascular disease.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)

• Upper GI perforations, ulcers or bleeds, some fatal; higher risk in elderly, with other NSAIDs or aspirin, or prior GI disease.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Selective COX-2 inhibitors may increase risk of thrombotic events (especially MI and stroke); risk may increase with dose and duration. Not a substitute for aspirin for cardiovascular prophylaxis.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)

• Oral anticoagulants (warfarin)Etoricoxib 120 mg daily increased INR by about 13%; monitor INR closely.electronic medicines compendium (emc)
• Diuretics, ACE inhibitors, angiotensin II antagonistsMay reduce antihypertensive effect; risk of further renal function deterioration in compromised patients; ensure hydration and monitor renal function.electronic medicines compendium (emc)
• Acetylsalicylic acidConcomitant use (even low dose) further increases the risk of GI adverse effects.electronic medicines compendium (emc)

• Contraindicated in pregnancy; no clinical data on exposed pregnancies; animal reproductive toxicity. Discontinue if pregnancy occurs.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Women who use etoricoxib must not breast-feed (excreted in rat milk; unknown in human milk).نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)

• Re-evaluate need for symptomatic relief periodically; monitor INR when starting or changing dose in patients on oral anticoagulants; consider renal function monitoring with ACE inhibitors/ARBs.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)

• Selective COX-2 inhibitor within the clinical dose range; no COX-1 inhibition at doses up to 150 mg daily (UK SmPC 5.1).