سعر سيدانيورين 20 قرص 2025

• Mild and moderate nervous tension and stress, mixed anxiety-depressive states, occasional or chronic insomnia, psychosomatic disorders (directory product description).Population: Adults

• Hypericum (well-established use): contraindicated with coumarin-type anticoagulants, ciclosporin, everolimus, sirolimus, systemic tacrolimus, protease inhibitors (e.g. indinavir, fosamprenavir), NRTIs, irinotecan, imatinib and other cytostatics metabolised by CYP3A4/2B6/2C9/2C19 or transported by P-glycoprotein; and in hypersensitivity.General active-ingredient information · European Medicines Agency (HMPC)
• Valerian: hypersensitivity to the active substance.General active-ingredient information · European Medicines Agency (HMPC)

• Hypericum: avoid intense UV exposure during treatment; use under 18 years not recommended (insufficient data).General active-ingredient information · European Medicines Agency (HMPC)
• Valerian: not recommended in children under 12 years; consult a doctor if symptoms worsen.General active-ingredient information · European Medicines Agency (HMPC)

• CYP3A4/CYP2B6/CYP2C9/CYP2C19 and P-glycoprotein substrates (e.g. amitriptyline, alprazolam, midazolam, methadone, simvastatin, digoxin)Hyperici herba preparations induce these enzymes/transporters and may reduce plasma concentrations of co-administered drugs.European Medicines Agency (HMPC)
• Hormonal contraceptivesReduced plasma concentrations may cause intermenstrual bleeding and reduced contraceptive reliability.European Medicines Agency (HMPC)

• Hypericum: safety in pregnancy and breast-feeding not established; animal studies showed reproductive toxicity; use not recommended.General active-ingredient information · European Medicines Agency (HMPC)
• Valerian: safety during pregnancy and lactation not established; use not recommended.General active-ingredient information · European Medicines Agency (HMPC)

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