دواعي استعمال Sigmadone 3mg 10 tab

Sigmadone 3 mg tablets (risperidone) by Sigma (Egypt), an atypical (second-generation) antipsychotic.

• Treatment of schizophrenia.الفئة: Adults and adolescents 13-17 yearsDailyMed (U.S. National Library of Medicine)
• Acute manic or mixed episodes of bipolar I disorder, as monotherapy or adjunct to lithium or valproate.الفئة: Adults; children/adolescents 10-17 years (monotherapy)DailyMed (U.S. National Library of Medicine)
• Irritability associated with autistic disorder.الفئة: Children and adolescents 5-17 yearsDailyMed (U.S. National Library of Medicine)

• Most common (>5% and twice placebo): parkinsonism, akathisia, dystonia, tremor, sedation, dizziness, anxiety, blurred vision, nausea, vomiting, abdominal pain, dyspepsia, diarrhoea, hypersalivation, constipation, dry mouth, increased appetite and weight, fatigue, rash, nasal congestion, upper respiratory infection.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to risperidone, paliperidone or any excipient (anaphylaxis and angioedema reported).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Boxed warning: increased mortality in elderly patients with dementia-related psychosis; not approved for dementia-related psychosis; cerebrovascular events including stroke reported in this population.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Neuroleptic malignant syndrome (hyperpyrexia, rigidity, altered mental status, autonomic instability): discontinue immediately and monitor.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Tardive dyskinesia; metabolic changes (hyperglycaemia/diabetes, dyslipidaemia, weight gain); hyperprolactinaemia; orthostatic hypotension; leukopenia, neutropenia and agranulocytosis (monitor CBC in at-risk patients).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Carbamazepine and other enzyme inducersDecrease risperidone plasma concentrations; increase the dose up to double the usual dose, titrating slowly.DailyMed (U.S. National Library of Medicine)
• Fluoxetine, paroxetine and other CYP2D6 inhibitorsIncrease risperidone concentrations; reduce the initial dose and do not exceed 8 mg/day.DailyMed (U.S. National Library of Medicine)

• Risperidone and 9-hydroxyrisperidone are present in breast milk (relative infant dose about 2.3-4.7%); sedation, failure to thrive, jitteriness and extrapyramidal symptoms reported in breastfed infants; monitor infants.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• ريسبيريدون: آلية التأثير في الفصام غير واضحة؛ قد يتم النشاط العلاجي عبر حصر مشترك لمستقبلات الدوبامين D2 والسيروتونين 5-HT2؛ وينتج التأثير السريري عن الريسبيريدون ومستقلبه النشط 9-هيدروكسي ريسبيريدون (باليبيريدون).