سعر سكيناترا مرهم 15 جم 2024

Skinatra topical ointment 15 gm (Zad Pharma, Egypt) containing chloramphenicol 10 mg/g and collagenase (clostridiopeptidase A) 0.6 unit/g, used for enzymatic debridement of wounds, ulcers and burns.

• Enzymatic cleansing of wounds: ulcers and necrosis (varicose, post-phlebitic and pressure ulcers; extremity gangrene, especially diabetic and frostbite), torpid post-operative, radiation and traumatic wounds, and before skin grafting.Population: AdultsAgenzia Italiana del Farmaco (AIFA)

• Common: hypersensitivity including allergic skin reactions, application-site pain, burning sensation and local eczematous (contact dermatitis) reactions; uncommon: erythema, pruritus; very rare: bone-marrow suppression including irreversible, potentially fatal aplastic anaemia after topical chloramphenicol.International label, same formulation · Agenzia Italiana del Farmaco (AIFA)

• Hypersensitivity to the active substances or to any excipient.International label, same formulation · Agenzia Italiana del Farmaco (AIFA)
• Use in paediatric patients.International label, same formulation · Agenzia Italiana del Farmaco (AIFA)
• Use in pregnancy.International label, same formulation · Agenzia Italiana del Farmaco (AIFA)

• Although rare, bone-marrow hypoplasia including aplastic anaemia and death has been reported after chloramphenicol use; use for short periods unless the physician directs otherwise, and routine blood counts before and during therapy may be advisable.International label, same formulation · Agenzia Italiana del Farmaco (AIFA)
• In diabetic patients with gangrene, excessive moisture from the product may increase infection risk; monitor the lesion carefully and regularly.International label, same formulation · Agenzia Italiana del Farmaco (AIFA)
• Prolonged topical use may cause irritation or sensitisation; stop promptly (even before 14 days) and treat appropriately; also stop if non-susceptible organisms develop.International label, same formulation · Agenzia Italiana del Farmaco (AIFA)

• Antiseptics or disinfectants (e.g. denatured alcohol, hydrogen peroxide, quaternary ammonium salts)Must not be used on the wound together with antiseptics or disinfectants (e.g. denatured alcohol, hydrogen peroxide, quaternary ammonium salts), which can inhibit the enzymatic activity.Agenzia Italiana del Farmaco (AIFA)
• Heavy-metal products (e.g. silver- and mercury-containing products)Must not be used on the wound together with heavy-metal products (e.g. silver- and mercury-containing products), which can inhibit the enzymatic activity.Agenzia Italiana del Farmaco (AIFA)
• Detergents and medicated soapsMust not be used on the wound together with detergents and medicated soaps, which can inhibit the enzymatic activity.Agenzia Italiana del Farmaco (AIFA)

• No reproductive or developmental toxicity studies; a risk to newborns cannot be excluded, so as a precaution it must not be used during pregnancy (contraindicated).International label, same formulation · Agenzia Italiana del Farmaco (AIFA)
• Insufficient data on excretion into breast milk; chloramphenicol excreted in milk has been linked to effects in infants; must not be used during breastfeeding.International label, same formulation · Agenzia Italiana del Farmaco (AIFA)

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