سعر سومادريل مركب 20 اقراص 2022

Somadril Compound is an Egyptian Minapharm tablet combining carisoprodol 200 mg, paracetamol 160 mg and caffeine 32 mg, pack of 20 tablets, presented by the manufacturer as a muscle relaxant analgesic.

• Manufacturer positioning: muscle relaxant analgesic.Minapharm Pharmaceuticals

• Most common (>2%) with carisoprodol: drowsiness, dizziness and headache.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• History of acute intermittent porphyria.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity to a carbamate such as meprobamate.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• The EU CHMP concluded (2007) that the risks of carisoprodol-containing medicines outweigh their benefits because of abuse and addiction, intoxication and psychomotor impairment, and blood levels often higher than expected at recommended doses; all EU marketing authorisations were suspended (EC decision 05/02/2008) and patients should not stop abruptly but be switched under medical advice.General active-ingredient information · European Medicines Agency (EMA)
• Sedation may impair driving or operating machinery; sedative effects are additive with other CNS depressants (alcohol, benzodiazepines, opioids, tricyclic antidepressants).General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Carisoprodol has been subject to abuse, dependence, withdrawal, misuse and diversion; abuse risks overdose with CNS and respiratory depression, hypotension, seizures and death.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• CNS depressants (alcohol, benzodiazepines, opioids, tricyclic antidepressants)Additive sedation; use caution; concomitant meprobamate not recommended.DailyMed (U.S. National Library of Medicine)
• CYP2C19 inhibitors (omeprazole, fluvoxamine) and inducers (rifampin, St John's wort)Inhibitors may raise carisoprodol and lower meprobamate exposure; inducers do the opposite; clinical impact unknown.DailyMed (U.S. National Library of Medicine)

• Decades of carisoprodol use in pregnancy have not identified a drug-associated risk of major birth defects, miscarriage or other adverse outcomes (carisoprodol component only).General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Carisoprodol and meprobamate pass into breast milk; one report of infant sedation; monitor breastfed infants for sedation.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

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