سعر سبيرسادكس كومب قطرة للعين 2022

Spersadex Comp chloramphenicol + dexamethasone eye drops (Excelvision/Novartis, Swiss-barcoded pack), 5 ml.

• Anterior-segment eye inflammation requiring corticosteroid with concurrent or high risk of chloramphenicol-susceptible bacterial infectionNovartis (document hosted by Medicar, Cyprus)

• Most frequent: local irritation or hypersensitivity (itching, redness, swelling, foreign-body sensation), burning/stinging and blurred vision; rare, sometimes irreversible blood dyscrasias (aplastic anaemia, pancytopenia, agranulocytosis) after ophthalmic chloramphenicol; rare reversible optic neuritis; raised intraocular pressure, cataract, secondary infection, ptosis, mydriasis; bitter taste.International label, same product · Novartis (document hosted by Medicar, Cyprus)

• Hypersensitivity to the active substances or excipients; corneal lesions from non-bacterial infections and ulcerative processes; herpes simplex and other viral infections; fungal infections; severe blood disorders due to bone-marrow depression and hepatic dysfunction; family history of bone-marrow depression; newborns (0-27 days).International label, same product · Novartis (document hosted by Medicar, Cyprus)

• Long-term chloramphenicol use, including topical ocular use, may very rarely cause bone-marrow aplasia. Prolonged corticosteroid use may raise intraocular pressure (monitor in glaucoma), contribute to posterior subcapsular cataract, mask or worsen infection and cause corneal/scleral perforation in thinning disease; caution in diabetes and with topical NSAIDs. Benzalkonium chloride may irritate the eye and discolour soft contact lenses.International label, same product · Novartis (document hosted by Medicar, Cyprus)

• Topical bactericidal antibiotics (penicillins, cephalosporins, gentamicin, tetracyclines, polymyxin B, vancomycin, sulfadiazine)Should not be used concurrently; bacteriostatic chloramphenicol can inhibit bactericidal action.Novartis (document hosted by Medicar, Cyprus)
• Systemic drugs causing haemopoietic damage (sulphonylureas, coumarins, hydantoins, methotrexate)Avoid as a precaution during systemic treatment with these drugs.Novartis (document hosted by Medicar, Cyprus)
• Topical NSAIDsWith significant pre-existing corneal inflammation, may increase risk of corneal complications.Novartis (document hosted by Medicar, Cyprus)

• Chloramphenicol in pregnancy can cause neonatal grey syndrome; ophthalmic dexamethasone was teratogenic in mice and rabbits; Spersadex Comp. should not be used during pregnancy.International label, same product · Novartis (document hosted by Medicar, Cyprus)
• Chloramphenicol is excreted in breast milk and may cause bone-marrow toxicity in infants; do not use while breastfeeding.International label, same product · Novartis (document hosted by Medicar, Cyprus)

• Chloramphenicol: Selective inhibition of bacterial protein synthesis (bacteriostatic).
• Dexamethasone sodium phosphate: Inhibits phospholipase A2 and formation of inflammatory mediators; about 25 times the anti-inflammatory potency of hydrocortisone.