دواعي استعمال سوبرانيم 500 / 500 مجم فيال عن طريق الوريد للاطفال

Imipenem 500 mg + cilastatin 500 mg powder vial for intravenous infusion; carbapenem antibacterial combination.

• Serious infections caused by susceptible bacteria including lower respiratory tract, urinary tract, intra-abdominal, gynaecologic, bacterial septicaemia, bone and joint, skin and skin-structure infections, and endocarditis (per US label)DailyMed (U.S. National Library of Medicine)

• Most frequent in adults: phlebitis, nausea, diarrhoea, vomiting, rash, injection-site pain, fever, hypotension, seizures, erythema at injection site, dizziness, pruritus, urticaria, somnolence.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to any component of the product.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Serious, occasionally fatal hypersensitivity (anaphylactic) reactions reported with beta-lactams.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Seizures and other CNS adverse experiences, especially when recommended doses are exceeded or in patients with CNS disorders or renal impairment.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Co-administration with valproic acid/divalproex reduces valproate concentrations and increases breakthrough seizure risk.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Clostridioides difficile-associated diarrhoea may occur.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Valproic acid / divalproex sodiumReduced valproate concentrations; increased risk of breakthrough seizures.DailyMed (U.S. National Library of Medicine)
• GanciclovirGeneralized seizures reported; avoid unless benefit outweighs risk.DailyMed (U.S. National Library of Medicine)
• ProbenecidIncreases imipenem plasma levels and half-life; not recommended.DailyMed (U.S. National Library of Medicine)

• Limited postmarketing data in pregnancy are insufficient to identify drug-associated risks of major birth defects, miscarriage or adverse outcomes.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Insufficient data on presence in human milk; consider benefits of breastfeeding against maternal need.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• إيميبينيم: Penem antibacterial that inhibits bacterial cell wall synthesis.
• سيلاستاتين: Inhibits renal dehydropeptidase, limiting renal metabolism of imipenem.