دواعي استعمال تينوفيناميد 25مجم 30 قرص

Tenofovir alafenamide 25 mg tablets for chronic hepatitis B, marketed in Egypt by Eva Pharma.

• Chronic hepatitis B virus infection with compensated liver disease.الفئة: Adults and pediatric patients >=6 years weighing >=25 kgDailyMed (U.S. National Library of Medicine)

• Most common adverse reaction (>=10%, all grades) is headache.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• None (US label).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Severe acute exacerbation of hepatitis B may occur after discontinuation; monitor clinically and with laboratory tests for at least several months.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Not recommended alone for HIV-1 infection due to resistance risk; offer HIV testing before starting.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• New onset or worsening renal impairment, including Fanconi syndrome and proximal renal tubulopathy, has been reported with TAF-containing products.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Lactic acidosis and severe hepatomegaly with steatosis have been reported with nucleoside analogs; suspend if suspected.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• P-gp inducersMay decrease tenofovir alafenamide absorption and plasma concentrations, with possible loss of effect.DailyMed (U.S. National Library of Medicine)
• Drugs reducing renal function or competing for tubular secretion (e.g., acyclovir, aminoglycosides, high-dose NSAIDs)May increase tenofovir concentrations and adverse reaction risk.DailyMed (U.S. National Library of Medicine)

• Antiretroviral Pregnancy Registry data show no statistically significant difference in overall birth defect risk versus background rate.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• TAF and tenofovir are present in human milk; no adverse effects on breastfed children reported; weigh benefits of breastfeeding against maternal need.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Monitor hepatic function for several months after discontinuation; assess renal function as clinically appropriate.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)