دواعي استعمال Tetracycline 250 mg 36 caps (B.P. 2012)

Tetracycline 250 mg oral capsules (36 capsules per pack; B.P. 2012 grade); tetracycline-class broad-spectrum antibiotic marketed in Egypt.

• Infections caused by susceptible strains of designated organisms, e.g. respiratory tract, skin and soft tissue infections (per US label list).الفئة: Adults and children over 8 yearsDailyMed (U.S. National Library of Medicine)

• Gastrointestinal effects (anorexia, nausea, epigastric distress, vomiting, diarrhoea, glossitis, dysphagia, enterocolitis); oesophagitis/oesophageal ulceration; rashes, exfoliative dermatitis, photosensitivity; tooth discoloration.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to any of the tetracyclines.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Use during tooth development (last half of pregnancy, infancy, childhood up to 8 years) may cause permanent yellow-grey-brown tooth discoloration and enamel hypoplasia; avoid in this age group except for anthrax unless other drugs are unsuitable.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Clostridioides difficile-associated diarrhoea has been reported with tetracyclines.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Intracranial hypertension (pseudotumor cerebri) has been associated with tetracyclines; avoid concomitant isotretinoin.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Penicillin / bactericidal antibacterialsBacteriostatic tetracycline may interfere with bactericidal action; avoid combination.DailyMed (U.S. National Library of Medicine)
• Oral anticoagulantsTetracyclines depress plasma prothrombin activity; anticoagulant dose may need reduction.DailyMed (U.S. National Library of Medicine)
• Antacids, iron, zinc, sodium bicarbonateImpair tetracycline absorption.DailyMed (U.S. National Library of Medicine)
• Oral contraceptivesConcurrent tetracycline may render oral contraceptives less effective.DailyMed (U.S. National Library of Medicine)

• Because of potential serious adverse reactions in nursing infants, decide whether to discontinue nursing or the drug.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Bacteriostatic; binds the 30S ribosomal subunit and inhibits bacterial protein synthesis (as described by the Egyptian directory and the US label).