دواعي استعمال ثيابريل 20/12.5مجم 20 اقراص

Enalapril 20 mg + hydrochlorothiazide 12.5 mg tablets (20 tablets (2 strips)) by Unipharma Co., Egypt; fixed-dose ACE inhibitor/diuretic antihypertensive.

• Hypertension (not indicated for initial therapy)الفئة: AdultsDailyMed (U.S. NLM)

• Hypersensitivity to any component; history of angioedema related to previous ACE inhibitor treatment; hereditary or idiopathic angioedema.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. NLM)
• Anuria or hypersensitivity to other sulfonamide-derived drugs (hydrochlorothiazide component).نشرة دولية لتركيبة مكافئة · DailyMed (U.S. NLM)
• Combination with a neprilysin inhibitor (e.g. sacubitril); do not give within 36 hours of switching to or from sacubitril/valsartan. Do not co-administer aliskiren in patients with diabetes.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. NLM)

• Boxed warning - fetal toxicity: drugs acting on the renin-angiotensin system can cause injury and death to the developing fetus; discontinue as soon as pregnancy is detected.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. NLM)
• Angioedema, reported with higher incidence in black patients receiving ACE inhibitors; agranulocytosis risk noted for ACE inhibitors (captopril), particularly in renal impairment or collagen vascular disease.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. NLM)
• Hydrochlorothiazide: non-melanoma skin cancer risk; protect skin from the sun and undergo regular skin cancer screening.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. NLM)

• Neprilysin inhibitors (sacubitril)Contraindicated; 36-hour washout when switching.DailyMed (U.S. NLM)

• Fetal toxicity: discontinue as soon as possible when pregnancy is detected (boxed warning).نشرة دولية لتركيبة مكافئة · DailyMed (U.S. NLM)
• Enalapril, enalaprilat and hydrochlorothiazide are detected in human breast milk; decide whether to discontinue nursing or the drug.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. NLM)