دواعي استعمال ثيوزين 25مجم 20 قرص

Thiozin 25 mg: thioridazine (phenothiazine antipsychotic) oral film-coated tablets by Delta Pharma, Egypt; pack of 20.

• Management of schizophrenic patients who fail to respond adequately to treatment with other antipsychotic drugs (reserved because of QTc-prolongation risk).الفئة: Adults and pediatric patients with schizophreniaDailyMed (U.S. National Library of Medicine)

• In recommended dose ranges most side effects are mild and transient; reported effects include endocrine disturbances (menstrual irregularities, gynecomastia, lactation, weight gain), urinary retention/incontinence and paradoxical behavioural reactions.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)

• Combination with other drugs known to prolong the QTc interval, and patients with congenital long QT syndrome or a history of cardiac arrhythmias.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
• Coadministration with CYP2D6 inhibitors (e.g. fluoxetine, paroxetine) or with fluvoxamine, propranolol or pindolol; patients known to have reduced CYP2D6 activity (about 7% of the population).نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
• Patients with a QTc interval greater than 450 msec should not receive thioridazine.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)

• Dose-related QTc prolongation with risk of torsades de pointes and sudden death; reserve for patients who failed at least two other antipsychotics.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
• Increased mortality in elderly patients with dementia-related psychosis treated with antipsychotic drugs.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
• Tardive dyskinesia and neuroleptic malignant syndrome may occur with antipsychotics.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
• Leukopenia/neutropenia and agranulocytosis have been reported; pigmentary retinopathy mainly at higher than recommended doses; caution with activities requiring alertness; avoid epinephrine for drug-induced hypotension.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)

• Fluoxetine, paroxetine and other CYP2D6 inhibitorsInhibit thioridazine metabolism, raising levels and QTc-related arrhythmia risk; contraindicated.DailyMed (U.S. National Library of Medicine)
• FluvoxamineInhibits thioridazine metabolism; contraindicated.DailyMed (U.S. National Library of Medicine)
• PropranololIncreases plasma thioridazine (about 50-400%) and metabolites; should not be coadministered.DailyMed (U.S. National Library of Medicine)
• PindololDose-related increases in thioridazine and pindolol levels; should not be coadministered.DailyMed (U.S. National Library of Medicine)
• Other QTc-prolonging drugsAdditive QTc prolongation; contraindicated.DailyMed (U.S. National Library of Medicine)

• Baseline ECG and serum potassium before starting; normalize potassium; consider periodic ECG and potassium, especially during dose adjustment; discontinue if QTc exceeds 500 msec.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
• Monitor complete blood count frequently in the first months in patients with pre-existing low WBC or history of drug-induced leukopenia/neutropenia.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)