دواعي استعمال ثرومبونورم 0.5 مجم 100 كبسولة

Anagrelide 0.5 mg oral capsules for thrombocythaemia (platelet-reducing agent), Egyptian product.

• Thrombocythaemia secondary to myeloproliferative neoplasms, to reduce elevated platelet count and thrombosis risk and ameliorate associated symptoms including thrombo-haemorrhagic events.DailyMed (U.S. National Library of Medicine)

• Most common (>=5%): headache, palpitations, diarrhoea, asthenia, oedema, nausea, abdominal pain, dizziness, pain, dyspnoea, cough, flatulence, vomiting, fever, peripheral oedema, rash, chest pain, anorexia, tachycardia, malaise, paraesthesia, back pain, pruritus, dyspepsia.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• The US label lists no contraindications.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Cardiovascular toxicity: QT prolongation, torsades de pointes and ventricular tachycardia reported; obtain pre-treatment cardiovascular exam including ECG; avoid in patients with QT-prolongation risk factors.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Pulmonary hypertension: assess underlying cardiopulmonary disease before starting.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Bleeding risk, especially with concomitant drugs that cause bleeding.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• QT-prolonging drugs (e.g. amiodarone, methadone, moxifloxacin, haloperidol)Avoid concomitant use.DailyMed (U.S. National Library of Medicine)
• Other PDE3 inhibitors / inotropes (e.g. cilostazol, milrinone)Exacerbation of inotropic effects; avoid.DailyMed (U.S. National Library of Medicine)
• Aspirin and other drugs that increase bleeding riskIncreased risk of bleeding.DailyMed (U.S. National Library of Medicine)

• Case-report data have not identified a drug-associated risk of major birth defects, miscarriage or adverse outcomes; thrombocythaemia itself carries maternal/fetal risk.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Breastfeeding is not recommended during treatment and for one week after the last dose.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Platelet counts weekly during titration, then monthly or as needed; ECG/cardiovascular evaluation before and during treatment.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)