دواعي استعمال ثرومبوستات محلول للحقن 12.5 مجم/50 مل

Tirofiban 12.5 mg/50 ml (250 micrograms/ml) concentrate for intravenous infusion, hospital use (GP IIb/IIIa antagonist).

• Prevention of early myocardial infarction in adults with NSTE-ACS (last chest pain within 12 h, with ECG changes and/or elevated cardiac enzymes), with aspirin and unfractionated heparin.الفئة: Adultselectronic medicines compendium (eMC)
• Reduction of major cardiovascular events in acute STEMI patients intended for primary PCI.الفئة: Adultselectronic medicines compendium (eMC)
• Reduce the rate of thrombotic cardiovascular events in NSTE-ACS.الفئة: AdultsDailyMed (U.S. National Library of Medicine)

• Bleeding is the most commonly reported adverse reaction.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity, or thrombocytopenia during earlier use of a GP IIb/IIIa antagonist.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Stroke within 30 days or any history of haemorrhagic stroke; known intracranial disease (neoplasm, AV malformation, aneurysm).نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Active or recent (within 30 days) clinically relevant bleeding; malignant hypertension; relevant trauma or major surgery within 6 weeks; platelets <100,000/mm3 or platelet-function disorders; clotting disturbances.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)

• Can cause serious bleeding, most often at the arterial access site; discontinue if bleeding cannot be controlled. Fibrinolytics, anticoagulants and antiplatelets increase bleeding risk.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
• Profound thrombocytopenia reported: check platelets about 6 hours after starting and daily; if confirmed, stop tirofiban and heparin.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)

• Fibrinolytics, anticoagulants, antiplatelet drugsIncreased risk of bleeding.DailyMed (U.S. National Library of Medicine)

• No or limited data in pregnant women; not recommended during pregnancy unless clearly necessary.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Unknown whether excreted in human milk (excreted in animal milk); decide whether to stop breastfeeding or therapy.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)

• Platelet count about 6 hours after start and daily thereafter; watch for bleeding.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)

• مضاد عكوس لارتباط الفيبرينوجين بمستقبل GP IIb/IIIa على الصفائح فيثبط تجمعها.مضاد لمستقبلات الجليكوبروتين IIb/IIIa؛ مضاد صفائح