دواعي استعمال ثروموكسيبان 20مجم 10 اقراص

Rivaroxaban 20 mg oral tablets (direct factor Xa inhibitor anticoagulant), Egyptian generic, 10 tablets.

• Reduce risk of stroke and systemic embolism in nonvalvular atrial fibrillation.الفئة: AdultsDailyMed (U.S. National Library of Medicine)
• Treatment of DVT and PE (continuation phase after the first 21 days).الفئة: AdultsDailyMed (U.S. National Library of Medicine)

• Most common adverse reaction in adults (>5%): bleeding.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Active pathological bleeding.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Severe hypersensitivity reaction to rivaroxaban (e.g. anaphylaxis).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Boxed warning: premature discontinuation increases the risk of thrombotic events; consider coverage with another anticoagulant if stopped for reasons other than bleeding or completion of therapy.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Boxed warning: epidural or spinal haematomas with neuraxial anaesthesia or spinal puncture, which may cause long-term or permanent paralysis; monitor neurological status.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Bleeding risk; the anticoagulant effect cannot be reliably monitored with standard laboratory tests.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Combined P-gp and strong CYP3A inhibitors (e.g. ketoconazole, ritonavir)Increase rivaroxaban exposure and bleeding risk; avoid.DailyMed (U.S. National Library of Medicine)
• Combined P-gp and strong CYP3A inducers (e.g. carbamazepine, phenytoin, rifampin, St John's wort)Decrease exposure and may increase thromboembolic risk; avoid.DailyMed (U.S. National Library of Medicine)
• Other anticoagulantsAvoid concomitant use.DailyMed (U.S. National Library of Medicine)
• Combined P-gp and moderate CYP3A inhibitors (e.g. erythromycin) in renal impairmentDo not use with CrCl 15 to <80 mL/min unless benefit justifies risk.DailyMed (U.S. National Library of Medicine)

• Limited data are insufficient to inform drug-associated risk; use with caution because of pregnancy-related haemorrhage and/or emergent delivery risk.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Rivaroxaban has been detected in human milk; weigh breastfeeding benefits against maternal need and possible infant effects.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Monitor for signs of bleeding and, around neuraxial procedures, for neurological impairment; assess renal function (CrCl) for dosing.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• مثبط مباشر عالي الانتقائية للعامل Xa فعال فموياً؛ تثبيط العامل Xa يقطع مساري التخثر الداخلي والخارجي فيمنع تكوين الثرومبين ونمو الجلطات؛ لا يثبط الثرومبين ولم يثبت له تأثير على الصفائح (النشرة الأوروبية).مثبط مباشر للعامل Xa