دواعي استعمال ثيروكسين 50مكجم 100 قرص

Thyroxine levothyroxine 50 microgram tablets, pack of 100 (T3A Pharma, Egypt); thyroid hormone replacement.

• Control of hypothyroidism, including congenital hypothyroidism in infants, acquired hypothyroidism in children and juvenile myxoedemaelectronic medicines compendium (emc), MHRA-authorised

• Usually signs of excessive dosage: palpitations, tachycardia, arrhythmia, angina, tremor, restlessness, insomnia, diarrhoea, vomiting, sweating, flushing, weight loss, headache, menstrual irregularity, muscle cramps/weakness; hypersensitivity; transient hair loss in children.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc), MHRA-authorised

• Hypersensitivity; thyrotoxicosis; adrenal insufficiency; must not be initiated in acute myocardial infarction, acute myocarditis or acute pancarditis; combination with antithyroid agents for hyperthyroidism is not indicated in pregnancy.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc), MHRA-authorised

• Introduce very gradually in patients over 50, in long-standing hypothyroidism and in cardiovascular disease; ECG before starting in patients at cardiac risk.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc), MHRA-authorised
• Start corticosteroids before levothyroxine in panhypopituitarism or adrenal insufficiency; insulin/antidiabetic requirements may increase; overtreatment risks atrial fibrillation and bone loss - titrate to lowest effective dose.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc), MHRA-authorised
• Boxed warning: thyroid hormones must not be used to treat obesity or for weight loss; larger doses can cause serious or life-threatening toxicity.نشرة دولية لتركيبة مكافئة · DailyMed (US National Library of Medicine)

• WarfarinAnticoagulant effect increased; anticoagulant dose may need reduction.electronic medicines compendium (emc), MHRA-authorised
• Antidiabetic agentsBlood glucose raised; dose adjustment may be required.electronic medicines compendium (emc), MHRA-authorised
• Tricyclic antidepressantsResponse accelerated; arrhythmias possible.electronic medicines compendium (emc), MHRA-authorised
• DigoxinDigoxin dose may need adjustment.electronic medicines compendium (emc), MHRA-authorised
• AmiodaroneMay reduce conversion of T4 to T3.electronic medicines compendium (emc), MHRA-authorised
• Carbamazepine, phenytoinEnhance metabolism of thyroid hormones.electronic medicines compendium (emc), MHRA-authorised

• Risk of fetal abnormality should be weighed against the risk of untreated hypothyroidism; combination with antithyroid drugs is not indicated in pregnancy.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc), MHRA-authorised
• US label: no increased rates of major birth defects or miscarriage reported; do not discontinue during pregnancy; monitor TSH and adjust dose.نشرة دولية لتركيبة مكافئة · DailyMed (US National Library of Medicine)
• Excreted in breast milk in low concentrations.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc), MHRA-authorised

• Monitor serum TSH (and T4) and adjust dose during long-term use; target TSH below 5 mU/L in younger patients without heart disease.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc), MHRA-authorised

• ليفوثيروكسين الصوديوم: Synthetic T4, converted peripherally to T3; acts like endogenous thyroid hormone to increase cellular metabolic rate.