دواعي استعمال تيلديم 60 مجم 20 قرص

Oral diltiazem hydrochloride 60 mg tablets, pack of 20, sold in Egypt under the Tildiem brand (benzothiazepine calcium-channel blocker).

• Prophylaxis and treatment of angina pectorisالفئة: Adultselectronic medicines compendium (emc), UK

• Reported effects include headache, dizziness, flushing, AV block, palpitations, bradycardia, constipation, dyspepsia, gastric pain, nausea, peripheral oedema, malaise and hepatic enzyme increases.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc), UK

• Hypersensitivity; sick sinus syndrome or 2nd/3rd-degree AV block without a functioning pacemaker; severe bradycardia (<50 bpm); left ventricular failure with pulmonary stasis; lactation; concurrent dantrolene infusion, ivabradine, lomitapide or asunaprevir.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc), UK

• Close observation in reduced left ventricular function, bradycardia, first-degree AV block or prolonged PR interval; acute renal failure has been reported in patients with cardiac disease.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc), UK
• May cause mood changes including depression, inhibit intestinal motility, raise blood glucose and induce bronchospasm; inform the anaesthetist before general anaesthesia.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc), UK

• Beta-blockersRisk of pronounced bradycardia, sinus arrest, conduction disturbances and heart failure; use only with close clinical and ECG monitoring.electronic medicines compendium (emc), UK
• Dantrolene (infusion)Combination contraindicated (risk of ventricular fibrillation seen with calcium antagonists in animals).electronic medicines compendium (emc), UK
• IvabradineContraindicated because of additive heart-rate lowering.electronic medicines compendium (emc), UK
• CiclosporinIncreases ciclosporin levels; reduce dose and monitor levels and renal function.electronic medicines compendium (emc), UK
• Carbamazepine / phenytoinIncreases their plasma levels; monitor concentrations.electronic medicines compendium (emc), UK
• Direct oral anticoagulantsDiltiazem is a moderate CYP3A4 and weak P-gp inhibitor; use caution, especially in patients at high bleeding risk.electronic medicines compendium (emc), UK

• Very limited human data and reproductive toxicity in animals; not recommended in pregnancy or in women of child-bearing potential not using effective contraception.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc), UK
• Excreted in breast milk; breastfeeding while taking diltiazem is contraindicated.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc), UK

• Monitor heart rate closely at the start of treatment, and renal function in patients with cardiac disease.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc), UK