دواعي استعمال تيمبيستاتين 10/20 مجم 14 قرص

Ezetimibe 10 mg + simvastatin 20 mg film-coated tablets, pack of 14; cholesterol absorption inhibitor combined with a statin.

• Adjunct to diet to reduce elevated LDL-C in adults with primary hyperlipidemiaالفئة: AdultsDailyMed (U.S. National Library of Medicine)
• Adjunct to diet to reduce LDL-C in heterozygous familial hypercholesterolemiaالفئة: Adults and children aged 10 years and olderDailyMed (U.S. National Library of Medicine)

• Common (>=2% and greater than placebo): headache, increased ALT, myalgia, upper respiratory tract infection, diarrhea.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Concomitant strong CYP3A4 inhibitors, cyclosporine, danazol or gemfibrozil; acute liver failure or decompensated cirrhosis; hypersensitivity to simvastatin, ezetimibe or excipients.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Myopathy and rhabdomyolysis, immune-mediated necrotizing myopathy, hepatic dysfunction, and increases in HbA1c/fasting glucose.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A4 inhibitors, cyclosporine, danazol, gemfibrozilContraindicated: increased risk of myopathy/rhabdomyolysis.DailyMed (U.S. National Library of Medicine)
• Coumarin anticoagulantsObtain INR before initiation and monitor during initiation or dose adjustment.DailyMed (U.S. National Library of Medicine)
• CholestyramineDecreases ezetimibe exposure.DailyMed (U.S. National Library of Medicine)
• FenofibratesIncrease ezetimibe exposure; evaluate gallbladder if cholelithiasis suspected.DailyMed (U.S. National Library of Medicine)

• Discontinue when pregnancy is recognized, or consider ongoing therapeutic needs; may cause fetal harm based on mechanism of action.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)