دواعي استعمال توفرانيل 25مجم 50 قرص

Imipramine 25 mg sugar-coated tablets, pack of 50 (tricyclic antidepressant).

• Relief of symptoms of depressionالفئة: AdultsDailyMed (U.S. National Library of Medicine)
• Temporary adjunctive therapy to reduce enuresis in children aged 6 years and older after organic causes are excludedالفئة: Children 6 years and olderDailyMed (U.S. National Library of Medicine)

• Cardiovascular: orthostatic hypotension, hypertension, tachycardia, palpitation, arrhythmias, heart block, ECG changes; plus psychiatric, neurological, anticholinergic and other tricyclic-class reactions listed in the label.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Concomitant use of monoamine oxidase inhibitors is contraindicated (hyperpyretic crises or severe convulsive seizures may occur); allow an adequate interval when switching.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Boxed warning: antidepressants increased the risk of suicidal thinking and behaviour in children, adolescents and young adults in short-term studies; monitor for clinical worsening and suicidality.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Extreme caution in cardiovascular disease (conduction defects, arrhythmias, heart failure, myocardial infarction, stroke, tachycardia), urinary retention, narrow-angle glaucoma, hyperthyroidism or thyroid medication; elderly and cardiac patients are at special risk of cardiac abnormalities.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• CYP2D6 inhibitors (e.g. quinidine, cimetidine, SSRIs such as fluoxetine, sertraline, paroxetine) and CYP2D6 substratesMay increase tricyclic plasma concentrations; caution when co-administering or switching from SSRIs.DailyMed (U.S. National Library of Medicine)

• No well-controlled studies in pregnant women; clinical reports of congenital malformations exist, causal relationship not confirmed; weigh benefit against possible hazard.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Limited data suggest imipramine is excreted in breast milk; as a general rule women taking the drug should not nurse.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Patients with cardiovascular disease require cardiac surveillance at all dosage levels; observe for clinical worsening, suicidality and unusual changes in behaviour.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• إيميبرامين: آلية العمل غير معروفة بشكل قاطع؛ ويُعتقد أنه يعزز المشابك الأدرينالية بمنع استرداد النورإبينفرين عند النهايات العصبية.مضاد اكتئاب ثلاثي الحلقات