سعر تولكسين Tolexine‏ 50مجم 14 كبسولة 2026

Doxycycline 50 mg oral capsules (Tolexine, Al Hikma Pharmaceuticals, Egypt), tetracycline-class antibacterial; pack of 14 capsules.

• Gastrointestinal effects (anorexia, nausea, vomiting, diarrhoea, glossitis, dysphagia, enterocolitis), rare oesophagitis/oesophageal ulceration, skin reactions including photosensitivity, rash, SJS/TEN, rise in BUN, hypersensitivity reactions and rare hepatotoxicity.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to any of the tetracyclines.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Use during tooth development (last half of pregnancy, infancy and childhood to 8 years) may cause permanent yellow-grey-brown tooth discoloration and enamel hypoplasia.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Clostridioides difficile-associated diarrhoea has been reported and may range from mild diarrhoea to fatal colitis, including more than two months after treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Antacids (aluminium, calcium, magnesium), iron preparations, bismuth subsalicylateImpair absorption of tetracyclines.DailyMed (U.S. National Library of Medicine)
• Oral anticoagulantsTetracyclines may depress plasma prothrombin activity; anticoagulant dose may need reduction.DailyMed (U.S. National Library of Medicine)
• Barbiturates, carbamazepine, phenytoin, rifampinShorten doxycycline half-life and lower its concentration.DailyMed (U.S. National Library of Medicine)

• No adequate well-controlled studies in pregnant women; expert (TERIS) review considered therapeutic doses unlikely to pose substantial teratogenic risk but data are insufficient to state there is no risk.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Tetracyclines are excreted in human milk; short-term use is not necessarily contraindicated but effects of prolonged exposure are unknown; decide whether to discontinue nursing or the drug.International label, same formulation · DailyMed (U.S. National Library of Medicine)