دواعي استعمال تونوكلون 400 مجم

Carbamazepine 400 mg tablets, 30 tablets (T3A Pharma, Egypt).

• Epilepsy: generalised tonic-clonic and partial seizures (not usually effective in absences or myoclonic seizures).electronic medicines compendium (emc), UK
• Paroxysmal pain of trigeminal neuralgia.electronic medicines compendium (emc), UK
• Prophylaxis of manic-depressive psychosis in patients unresponsive to lithium.electronic medicines compendium (emc), UK

• Very common/common, especially early or at high doses: dizziness, headache, ataxia, drowsiness, fatigue, diplopia and gastrointestinal effects.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc), UK

• Hypersensitivity to carbamazepine or structurally related drugs (e.g. tricyclic antidepressants).نشرة دولية لنفس التركيبة · electronic medicines compendium (emc), UK
• Atrioventricular block, history of bone marrow depression, or history of hepatic porphyrias.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc), UK
• Combination with MAO inhibitors; stop MAOIs at least 2 weeks before starting carbamazepine.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc), UK

• Screen patients of Han Chinese and Thai origin for HLA-B*1502 before starting (risk of Stevens-Johnson syndrome).نشرة دولية لنفس التركيبة · electronic medicines compendium (emc), UK
• Agranulocytosis and aplastic anaemia have been associated with carbamazepine.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc), UK
• Monitor for suicidal ideation and behaviour, as with other antiepileptics.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc), UK
• May make hormonal contraceptives ineffective; non-hormonal contraception is recommended.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc), UK
• Ataxia, dizziness, somnolence and hypotension may lead to falls.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc), UK

• CYP3A4 inhibitors (e.g. macrolides, azole antifungals, ritonavir, diltiazem, verapamil, grapefruit juice)May raise carbamazepine levels and cause dizziness, drowsiness, ataxia or diplopia; adjust dose or monitor levels.electronic medicines compendium (emc), UK
• Drugs metabolised by CYP3A4Carbamazepine is a potent enzyme inducer and may lower their plasma concentrations.electronic medicines compendium (emc), UK

• First-trimester exposure increases the risk of major congenital malformations and neurodevelopmental disorders; use in pregnancy only if benefit outweighs risk, at the lowest effective dose as monotherapy.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc), UK
• Passes into breast milk (about 25-60% of plasma levels); breastfeeding possible with observation of the infant for adverse effects.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc), UK

• Plasma carbamazepine levels (about 4-12 micrograms/mL) may help optimise dosing in epilepsy.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc), UK