دواعي استعمال توراسيمايد 10مجم 10 اقراص

Torsemide (torasemide) 10 mg oral tablets, pack of 10, by Alexandria Co. (Egypt); loop diuretic.

• علاج الوذمة المصاحبة لقصور القلب أو أمراض الكلى أو أمراض الكبد.DailyMed (U.S. National Library of Medicine)
• علاج ارتفاع ضغط الدم لخفض الضغط.DailyMed (U.S. National Library of Medicine)

• Excessive urination was the most notable adverse reaction in US placebo-controlled hypertension trials (dose related: 4% at 5 mg, 15% at 10 mg vs 1% placebo).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to torsemide; anuria; hepatic coma.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Excessive diuresis may cause dehydration, hypotension and worsening renal function, including acute renal failure, especially in salt-depleted patients or those on renin-angiotensin-aldosterone inhibitors.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• May cause hypokalemia, hyponatremia, hypomagnesemia, hypocalcemia, hypochloremic alkalosis, hyperglycemia and hyperuricemia (rarely gout).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Ototoxicity (tinnitus, usually reversible hearing loss) has been observed with loop diuretics; risk increases with high doses, severe renal impairment and hypoproteinemia.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• NSAIDs / high-dose salicylatesNSAIDs may reduce the diuretic/antihypertensive effect and have been associated with acute renal failure; high-dose salicylates may reach toxic levels because of competition for renal tubular secretion.DailyMed (U.S. National Library of Medicine)
• CYP2C9 inhibitors and inducersCYP2C9 inhibitors (e.g., amiodarone, fluconazole) increase and inducers (e.g., rifampin) decrease torsemide levels; torsemide may affect CYP2C9 substrates such as warfarin, phenytoin, celecoxib.DailyMed (U.S. National Library of Medicine)
• LithiumReduced renal clearance of lithium with high risk of lithium toxicity; monitor lithium levels.DailyMed (U.S. National Library of Medicine)
• Aminoglycosides and other ototoxic drugsIncreased ototoxic potential; avoid concomitant aminoglycosides if possible.DailyMed (U.S. National Library of Medicine)
• CholestyramineMay reduce torsemide absorption; give torsemide at least 1 hour before or 4-6 hours after cholestyramine.DailyMed (U.S. National Library of Medicine)
• ACE inhibitors / angiotensin receptor blockersIncreased risk of hypotension and renal impairment.DailyMed (U.S. National Library of Medicine)
• Corticosteroids and ACTHIncreased risk of hypokalemia.DailyMed (U.S. National Library of Medicine)

• No available data in pregnant women on major birth defects or miscarriage; no fetotoxicity or teratogenicity in rats and rabbits at moderate multiples of the human dose, but maternal/fetal toxicity at higher multiples.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• No data on presence in human milk or effects on the breastfed child; diuretics can suppress lactation.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Monitor volume status, renal function, serum electrolytes and blood glucose periodically.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• تورسيميد: يثبط ناقل الصوديوم-البوتاسيوم-الكلوريد في الطرف الصاعد السميك لعروة هنلي فيزيد إخراج الصوديوم والكلوريد والماء.مدر بول عروة (سقف عالٍ) — بيريدين سلفونيل يوريا