دواعي استعمال ترافونورم بلس 0.004%/0.55 قطرة للعين 5مل 0.004%/0.5%

Fixed-combination travoprost + timolol eye drops, 5 mL bottle. Strength 0.004%/0.5% per the Egyptian listing.

• خفض ضغط العين لدى البالغين المصابين بالزرق مفتوح الزاوية أو ارتفاع ضغط العين الذين لا يستجيبون بشكل كافٍ لحاصرات بيتا أو نظائر البروستاجلاندين الموضعيةالفئة: Adultselectronic medicines compendium (emc), UK

• Most frequent treatment-related adverse reaction in clinical studies (2,170 patients) was ocular hyperaemia (12.0%).نشرة دولية لنفس التركيبة · electronic medicines compendium (emc), UK

• Hypersensitivity to the active substances, excipients or other beta blockers; reactive airway disease including bronchial asthma or history of asthma, severe COPD; sinus bradycardia, sick sinus syndrome, sino-atrial block, uncontrolled second- or third-degree AV block; overt cardiac failure, cardiogenic shock; severe allergic rhinitis and corneal dystrophies.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc), UK

• Timolol is absorbed systemically: beta-blocker cardiovascular and pulmonary reactions can occur (caution in cardiovascular disease, first-degree heart block, severe peripheral circulatory disorders, mild/moderate COPD); bronchospasm deaths reported with ophthalmic beta blockers in asthma; may mask hypoglycaemia; may potentiate myasthenic weakness; caution in corneal disease.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc), UK
• Travoprost component may increase iris pigmentation and change eyelashes and periorbital tissue.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc), UK

• Oral calcium channel blockers, beta blockers, antiarrhythmics (incl. amiodarone), digitalis glycosides, parasympathomimetics, guanethidinePotential additive effects resulting in hypotension and/or marked bradycardia.electronic medicines compendium (emc), UK
• CYP2D6 inhibitors (e.g. quinidine, fluoxetine, paroxetine)Potentiated systemic beta blockade (e.g. decreased heart rate, depression) reported with timolol.electronic medicines compendium (emc), UK
• ClonidineHypertensive reaction to sudden clonidine withdrawal can be potentiated by beta blockers.electronic medicines compendium (emc), UK
• Antidiabetic medicinesBeta blockers may increase the hypoglycaemic effect and mask signs of hypoglycaemia.electronic medicines compendium (emc), UK

• Travoprost has harmful pharmacological effects on pregnancy and/or the fetus/newborn; do not use during pregnancy unless clearly necessary. Must not be used in women of childbearing potential unless adequate contraception is in place.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc), UK
• Timolol is excreted in breast milk; travoprost excretion in human milk unknown (excreted in animal milk). Use by breast-feeding women is not recommended.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc), UK