دواعي استعمال تريبي 250مجم 10 اقراص

Trerbi 250 mg tablets containing terbinafine, an allylamine antifungal, marketed in Egypt by Mash Premiere.

• Onychomycosis of the toenail or fingernail due to dermatophytes (tinea unguium)الفئة: AdultsDailyMed (U.S. National Library of Medicine)

• Headache, diarrhea, rash, dyspepsia, liver enzyme abnormalities, pruritus, taste disturbance, nausea, abdominal pain, flatulence.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Chronic or active liver disease; history of allergic reaction to oral terbinafine.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Hepatotoxicity including liver failure leading to transplant or death; obtain baseline liver tests and discontinue if liver injury develops.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Taste and/or smell disturbance, possibly prolonged or permanent.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Depressive symptoms.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Severe neutropenia (monitor CBC if therapy >6 weeks in immunodeficient patients).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Serious skin/hypersensitivity reactions (SJS, TEN, DRESS), lupus erythematosus, thrombotic microangiopathy and rhabdomyolysis reported.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• CYP2D6 substrates (e.g. desipramine, TCAs, SSRIs, beta-blockers, type 1C antiarrhythmics, MAO-B inhibitors)Terbinafine inhibits CYP2D6 and can increase their levels; dose reduction may be needed.DailyMed (U.S. National Library of Medicine)
• Fluconazole and other dual CYP2C9/CYP3A4 inhibitorsIncrease terbinafine exposure.DailyMed (U.S. National Library of Medicine)
• Cimetidine / rifampinCimetidine decreases and rifampin increases terbinafine clearance.DailyMed (U.S. National Library of Medicine)
• CyclosporineTerbinafine increases cyclosporine clearance.DailyMed (U.S. National Library of Medicine)
• CaffeineTerbinafine decreases IV caffeine clearance.DailyMed (U.S. National Library of Medicine)

• Available postmarketing data are insufficient to evaluate a drug-associated risk of major birth defects, miscarriage or adverse outcomes; no fetal harm in rat/rabbit studies at up to 12-23 times the MRHD (US label).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Terbinafine is present in human milk after oral administration; no data on effects on the breastfed child; weigh benefits of breastfeeding against maternal need (US label).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Baseline liver function tests; monitor for signs of liver injury; CBC if treatment exceeds 6 weeks in immunodeficient patients.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)