دواعي استعمال تريباتنس 40/10/25 مجم 30 قرص

Olmesartan medoxomil 40 mg + amlodipine 10 mg + hydrochlorothiazide 25 mg film-coated tablets, pack of 30 (Rameda, Egypt).

• علاج ارتفاع ضغط الدمالفئة: AdultsDailyMed (U.S. National Library of Medicine)

• Most common: dizziness, peripheral oedema, headache, fatigue, nasopharyngitis, muscle spasms, nausea, upper respiratory tract infection, diarrhoea, urinary tract infection, joint swelling.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Anuria; hypersensitivity to any component or to other sulfonamide-derived drugs (hydrochlorothiazide component).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Do not co-administer aliskiren in patients with diabetes.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Hypotension in volume- or salt-depleted patients: correct before administration.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Increased angina or myocardial infarction may occur on starting or increasing a calcium channel blocker.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Electrolyte and metabolic imbalances: hypokalaemia, hyponatraemia, hypomagnesaemia (HCTZ) or hyperkalaemia (olmesartan); may alter glucose tolerance.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Impaired renal function; exacerbation or activation of systemic lupus erythematosus; acute angle-closure glaucoma (HCTZ).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Sprue-like enteropathy has been reported with olmesartan; consider discontinuation when no other aetiology is found.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• NSAIDs (including COX-2 inhibitors)May increase risk of renal impairment and reduce antihypertensive and diuretic effect.DailyMed (U.S. National Library of Medicine)
• Dual RAS blockade (ACE inhibitors, ARBs, aliskiren)Increased risk of renal impairment, hypotension and hyperkalaemia; aliskiren contraindicated in diabetes.DailyMed (U.S. National Library of Medicine)
• LithiumIncreases in serum lithium concentrations and lithium toxicity.DailyMed (U.S. National Library of Medicine)
• ColesevelamGive olmesartan at least 4 hours before colesevelam.DailyMed (U.S. National Library of Medicine)
• SimvastatinLimit simvastatin to 20 mg daily with amlodipine.DailyMed (U.S. National Library of Medicine)
• Cyclosporine, tacrolimusAmlodipine may increase their exposure.DailyMed (U.S. National Library of Medicine)
• Strong/moderate CYP3A inhibitorsIncreased amlodipine exposure.DailyMed (U.S. National Library of Medicine)
• Antidiabetic drugs; cholestyramine/colestipolAntidiabetic dose adjustment may be needed; bile acid resins reduce thiazide absorption.DailyMed (U.S. National Library of Medicine)

• BOXED WARNING - fetal toxicity: drugs acting directly on the renin-angiotensin system can cause injury and death to the developing fetus; discontinue as soon as pregnancy is detected.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Breastfeeding is not recommended.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Monitor renal function and potassium in susceptible patients; observe for fluid or electrolyte imbalance.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)