سعر تريلازين Trilazine‏ 4مجم 10 اقراص 2026

Perphenazine 4 mg film-coated tablets, pack of 10, by Sigma (Egypt); phenothiazine antipsychotic.

• Extrapyramidal reactions (dystonia, akathisia, parkinsonism, tardive dyskinesia), drowsiness, hypotension, anticholinergic effects (dry mouth, blurred vision, constipation, urinary retention), hyperprolactinaemia effects, photosensitivity, blood dyscrasias and cholestatic jaundice.International label, same formulation · DailyMed (US National Library of Medicine)

• Comatose or greatly obtunded patients, and patients receiving large doses of CNS depressants (barbiturates, alcohol, narcotics, analgesics, antihistamines).International label, same formulation · DailyMed (US National Library of Medicine)
• Blood dyscrasias, bone marrow depression or liver damage; hypersensitivity to perphenazine or other phenothiazines.International label, same formulation · DailyMed (US National Library of Medicine)
• Suspected or established subcortical brain damage, with or without hypothalamic damage (risk of hyperthermic reaction).International label, same formulation · DailyMed (US National Library of Medicine)

• Boxed warning: elderly patients with dementia-related psychosis treated with antipsychotics are at increased risk of death; perphenazine is not approved for dementia-related psychosis.International label, same formulation · DailyMed (US National Library of Medicine)
• Tardive dyskinesia and neuroleptic malignant syndrome may occur; discontinue if signs appear where clinically appropriate.International label, same formulation · DailyMed (US National Library of Medicine)
• Leukopenia, neutropenia and agranulocytosis have been reported; monitor complete blood count frequently in the first months in patients with risk factors and discontinue at the first sign of a significant decline.International label, same formulation · DailyMed (US National Library of Medicine)

• CYP2D6 inhibitors (e.g. SSRIs such as fluoxetine, sertraline, paroxetine; tricyclic antidepressants)Inhibit perphenazine metabolism and raise plasma levels; CYP2D6 poor metabolizers also have higher concentrations; lower doses may be needed.DailyMed (US National Library of Medicine)
• CNS depressants (alcohol, barbiturates, opioids, anaesthetics, antihistamines)Additive CNS depression; contraindicated with large doses.DailyMed (US National Library of Medicine)

• Safe use in pregnancy has not been established; use only if the potential benefit justifies the potential risk to the fetus.International label, same formulation · DailyMed (US National Library of Medicine)
• Safe use during lactation has not been established; weigh the benefit against possible hazards to the infant.International label, same formulation · DailyMed (US National Library of Medicine)

• Perphenazine: Blocks dopamine D1 and D2 receptors in the brain, including the chemoreceptor trigger zone.