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دواعي استعمال تريتيكو 100مجم 20 قرص

معلومات من نشرات دوائية ومراجع موثقة، مع مصدر كل معلومة. السعر الحالي: 60ج.م.

دواعي الاستعمال
  • علاج اضطراب الاكتئاب الجسيم لدى البالغين.الفئة: AdultsDailyMed (U.S. National Library of Medicine)
الآثار الجانبية
  • Most common adverse reactions (incidence at least 5% and twice placebo): oedema, blurred vision, syncope, drowsiness, fatigue, diarrhoea, nasal congestion and weight loss.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
موانع الاستعمال
  • يمنع استخدامه مع مثبطات أكسيداز أحادي الأمين (بما في ذلك اللينزوليد أو الميثيلين الأزرق الوريدي) أو خلال 14 يوماً من إيقافها.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
تحذيرات واحتياطات
  • Boxed warning: antidepressants increased the risk of suicidal thoughts and behaviours in paediatric and young adult patients; monitor all patients for clinical worsening and emergence of suicidal thoughts.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
  • Serotonin syndrome, especially with other serotonergic drugs (SSRIs, SNRIs, triptans); discontinue and treat supportively if it occurs.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
  • Cardiac arrhythmias: trazodone prolongs the QT interval (torsade de pointes reported at 100 mg or less with the immediate-release form); avoid with other QT-prolonging drugs and in patients with arrhythmia risk factors.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
  • Orthostatic hypotension and syncope.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
  • Increased risk of bleeding with aspirin, NSAIDs, other antiplatelet drugs, warfarin and other anticoagulants.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
  • Priapism: men with an erection lasting more than 4 hours should stop the drug and seek emergency care; use with caution in conditions predisposing to priapism.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
  • Activation of mania or hypomania: screen for personal or family history of bipolar disorder before starting.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
  • Discontinuation syndrome on abrupt withdrawal; potential for cognitive and motor impairment (sedation).نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
  • Angle-closure glaucoma: avoid in patients with untreated anatomically narrow angles.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
  • Hyponatraemia (often SIADH-related), particularly in the elderly.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
التداخلات الدوائية
  • MAOIsContraindicated (serotonin syndrome); allow at least 14 days between stopping an MAOI and starting trazodone and vice versa.DailyMed (U.S. National Library of Medicine)
  • Strong CYP3A4 inhibitorsIncrease trazodone exposure; consider dose reduction based on tolerability.DailyMed (U.S. National Library of Medicine)
  • Strong CYP3A4 inducersDecrease trazodone exposure; a dose increase may be necessary.DailyMed (U.S. National Library of Medicine)
  • Alcohol, barbiturates and other CNS depressantsTrazodone may enhance their effects.DailyMed (U.S. National Library of Medicine)
  • Digoxin or phenytoinMonitor for increased serum levels.DailyMed (U.S. National Library of Medicine)
  • WarfarinMonitor prothrombin time (increased or decreased).DailyMed (U.S. National Library of Medicine)
الحمل والرضاعة
  • Published prospective cohort studies, case series and case reports over several decades have not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes; animal studies showed fetal effects at about 7.3-11 times the maximum human dose. A pregnancy exposure registry exists for antidepressants.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
  • Trazodone transfers into human milk; limited postmarketing data have not identified adverse effects on the breastfed child; weigh benefits of breastfeeding against maternal need.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
المتابعة أثناء العلاج
  • Monitor for clinical worsening, suicidality and unusual changes in behaviour, especially at initiation and dose changes; consider ECG in patients with cardiac risk factors; monitor sodium in at-risk patients.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
كيف يعمل الدواء
  • ترازودون: Mechanism of antidepressant action not fully understood; thought to be related to enhancement of serotonergic activity in the CNS (US label).
سعر تريتيكو 100مجم 20 قرصالمثائل والبدائل

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