دواعي استعمال توينزول قطرة عين 5 مل

Twinzol (Orchidia, Egypt) dorzolamide 20 mg/ml + timolol 5 mg/ml eye drops, 5 ml bottle.

• Reduction of elevated intraocular pressure in open-angle or pseudoexfoliative glaucoma when beta-blocker monotherapy is not sufficientOrchidia Pharmaceutical Industries
• Reduction of elevated IOP in open-angle glaucoma or ocular hypertension in patients insufficiently responsive to beta-blockersDailyMed (U.S. National Library of Medicine)

• Most common (up to ~30%): taste perversion (bitter/sour taste), ocular burning and/or stinging; also conjunctival hyperemia, blurred vision, superficial punctate keratitis, eye itching.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Bronchial asthma or history of asthma, severe COPD; sinus bradycardia, second/third-degree AV block, overt cardiac failure, cardiogenic shock; hypersensitivity to any component.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Timolol is absorbed systemically: may cause respiratory and cardiac reactions (including death from bronchospasm in asthma, and cardiac failure). Dorzolamide is a sulfonamide; severe sulfonamide reactions may occur. Not recommended in severe renal impairment (CrCl <30 mL/min).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Oral carbonic anhydrase inhibitorsPotential additive effects; concomitant use not recommended.DailyMed (U.S. National Library of Medicine)
• Systemic beta-blockersMay potentiate systemic beta-blockade.DailyMed (U.S. National Library of Medicine)
• Oral or IV calcium antagonistsMay cause AV conduction disturbances, left ventricular failure and hypotension.DailyMed (U.S. National Library of Medicine)
• Catecholamine-depleting drugs (e.g. reserpine)Possible additive hypotension and/or marked bradycardia.DailyMed (U.S. National Library of Medicine)
• DigitalisAdditive prolongation of AV conduction time with calcium antagonists/digitalis.DailyMed (U.S. National Library of Medicine)

• No adequate and well-controlled studies in pregnant women; no teratogenicity in animals at clinically relevant doses (vertebral malformations in rabbits only at maternally toxic oral dorzolamide doses).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Unknown whether excreted in human milk (timolol is detected in milk after oral dosing); exercise caution and weigh benefits against risks.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)