دواعي استعمال يو اف تي 28 كبسول

Tegafur/uracil oral capsule (fluoropyrimidine antimetabolite) used with folinic acid for metastatic colorectal cancer.

• First-line treatment of metastatic colorectal cancer, in combination with folinic acid.الفئة: AdultsANSM - Base de données publique / ecodex (France)

• Diarrhoea, nausea/vomiting, abdominal pain, asthenia and bone marrow suppression are among the most frequent reactions.نشرة دولية لنفس التركيبة · ANSM - Base de données publique / ecodex (France)

• Pregnancy and breastfeeding; children; severe hepatic impairment; severe bone marrow depression; known CYP2A6 deficiency; known complete DPD deficiency; recent or concomitant treatment with DPD inhibitors such as brivudine (4-week interval required).نشرة دولية لنفس التركيبة · ANSM - Base de données publique / ecodex (France)

• Brivudine and other DPD inhibitorsContraindicated: risk of fatal fluoropyrimidine toxicity; respect a 4-week interval.ANSM - Base de données publique / ecodex (France)
• Warfarin / coumarin anticoagulantsIncreased INR/bleeding risk; monitor coagulation.ANSM - Base de données publique / ecodex (France)
• PhenytoinIncreased phenytoin levels; monitor.ANSM - Base de données publique / ecodex (France)

• Contraindicated during pregnancy.نشرة دولية لنفس التركيبة · ANSM - Base de données publique / ecodex (France)
• Contraindicated during breastfeeding.نشرة دولية لنفس التركيبة · ANSM - Base de données publique / ecodex (France)