دواعي استعمال التراموكس 1 جم 12 قرص

Ultramox 1 g: amoxicillin + clavulanic acid film-coated tablets, total strength 1 g, pack of 12; broad-spectrum oral antibiotic (Pharco/Amriya).

• Infections caused by susceptible beta-lactamase-producing isolates: lower respiratory tract infections, acute bacterial otitis media, sinusitis, skin and skin-structure infections, urinary tract infectionsDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (>=3%): diarrhoea/loose stools, nausea, skin rashes and urticaria, vomiting and vaginitis.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)

• History of serious hypersensitivity reaction (e.g. anaphylaxis or Stevens-Johnson syndrome) to amoxicillin, clavulanate or other beta-lactams (penicillins, cephalosporins).نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
• History of cholestatic jaundice/hepatic dysfunction associated with amoxicillin/clavulanate.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)

• Serious and occasionally fatal hypersensitivity (anaphylactic) reactions; discontinue and institute appropriate therapy if an allergic reaction occurs.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
• Severe cutaneous adverse reactions (SJS, TEN, DRESS, AGEP) and drug-induced enterocolitis syndrome have been reported; discontinue if they occur.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
• Hepatic dysfunction, including hepatitis and cholestatic jaundice, has been reported, mainly in elderly men and with prolonged treatment.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
• Clostridioides difficile-associated diarrhoea has been reported.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
• Avoid in patients with mononucleosis because of a high incidence of erythematous skin rash.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)

• ProbenecidProbenecid decreases renal tubular secretion of amoxicillin; co-administration is not recommended.DailyMed (U.S. National Library of Medicine)
• Oral anticoagulantsAbnormal prolongation of prothrombin time (increased INR) has been reported; monitor and adjust the anticoagulant dose as needed.DailyMed (U.S. National Library of Medicine)
• AllopurinolConcomitant use increases the incidence of rashes.DailyMed (U.S. National Library of Medicine)
• Oral contraceptivesMay affect gut flora, leading to lower oestrogen reabsorption and reduced efficacy of combined oral oestrogen/progesterone contraceptives.DailyMed (U.S. National Library of Medicine)

• Available data from published studies have not established a drug-associated risk of major birth defects or miscarriage; in women with preterm premature rupture of membranes, prophylactic amoxicillin/clavulanate may be associated with an increased risk of necrotising enterocolitis in neonates.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)