دواعي استعمال زوسيلين 4.5 جم بي دي امبول

Zocillin 4.5 g powder for intravenous injection containing piperacillin with the beta-lactamase inhibitor tazobactam, by Eva Pharma, Egypt.

• Intra-abdominal infections and nosocomial pneumonia (adults and children 2 months and older); skin and skin-structure infections, female pelvic infections and community-acquired pneumonia in adults, caused by susceptible bacteria.الفئة: Adults and children >= 2 monthsDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (>5%): diarrhoea, constipation, nausea, headache and insomnia.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• History of allergic reactions to any penicillin, cephalosporin or beta-lactamase inhibitor.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Serious hypersensitivity (anaphylactic) reactions and severe cutaneous adverse reactions (SJS, TEN, DRESS, AGEP) may occur; discontinue if they develop. Haemophagocytic lymphohistiocytosis and rhabdomyolysis have been reported.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• TobramycinCan significantly reduce tobramycin concentrations in haemodialysis patients; monitor tobramycin levels.DailyMed (U.S. National Library of Medicine)
• ProbenecidProlongs the half-lives of piperacillin and tazobactam; avoid co-administration unless benefit outweighs risk.DailyMed (U.S. National Library of Medicine)
• VancomycinCo-administration may increase the incidence of acute kidney injury; monitor kidney function.DailyMed (U.S. National Library of Medicine)

• Piperacillin and tazobactam cross the placenta; human data are insufficient to establish a drug-associated risk of major birth defects or miscarriage. No structural fetal abnormalities in rats or mice; fetotoxicity was seen with maternal toxicity.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)