دواعي استعمال زوكور 10مجم 7 قرص

Zocor 10 mg film-coated tablets containing simvastatin (HMG-CoA reductase inhibitor), MSD brand listed with Global Napi Pharmaceuticals, Egypt.

• Reduce risk of total mortality, coronary death, non-fatal MI, stroke and revascularisation in high-risk adults; adjunct to diet to reduce LDL-C in primary hyperlipidaemia, heterozygous familial hypercholesterolaemia (adults and children 10 years and older) and, with other therapies, homozygous FH.الفئة: Adults; children >= 10 years with HeFHDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (>=5%): upper respiratory infection, headache, abdominal pain, constipation and nausea.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Concomitant strong CYP3A4 inhibitors, cyclosporine, danazol or gemfibrozil; acute liver failure or decompensated cirrhosis; hypersensitivity to simvastatin or excipients.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Myopathy and rhabdomyolysis: risk increases with age 65 years or older, uncontrolled hypothyroidism, renal impairment, interacting drugs and higher doses; discontinue if CK is markedly elevated or myopathy is suspected; report unexplained muscle pain or weakness promptly.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Coumarin anticoagulantsObtain INR before starting and monitor during initiation or dose changes.DailyMed (U.S. National Library of Medicine)
• Grapefruit juice and CYP3A4 inhibitorsIncrease the risk of myopathy and rhabdomyolysis; see label restrictions.DailyMed (U.S. National Library of Medicine)

• Discontinue when pregnancy is recognised (or weigh ongoing therapeutic need); may cause fetal harm based on mechanism of action.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Breastfeeding is not recommended during treatment.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Assess LDL-C as early as 4 weeks after starting or adjusting the dose; monitor INR with coumarins and digoxin levels on initiation.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)