دواعي استعمال زوكوزيت 10/10مجم 14 قرص

Zocozet 10/10 mg film-coated tablets combining ezetimibe and simvastatin, by Marcyrl Co. (Geopharma-Egypt), Egypt.

• Adjunct to diet to reduce elevated LDL-C in adults with primary hyperlipidaemia, in adults and children 10 years and older with heterozygous familial hypercholesterolaemia, and with other LDL-lowering therapies in homozygous FH.الفئة: Adults; children >= 10 years with HeFHDailyMed (U.S. National Library of Medicine)

• Common adverse reactions: headache, increased ALT, myalgia, upper respiratory tract infection and diarrhoea.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Concomitant strong CYP3A4 inhibitors, cyclosporine, danazol or gemfibrozil; acute liver failure or decompensated cirrhosis; hypersensitivity to simvastatin, ezetimibe or excipients.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Myopathy and rhabdomyolysis: risk increases with age 65 years or older, uncontrolled hypothyroidism, renal impairment, interacting drugs and higher doses; discontinue if CK is markedly elevated or myopathy is suspected.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• CholestyramineDecreases ezetimibe exposure.DailyMed (U.S. National Library of Medicine)
• FenofibratesIncrease ezetimibe exposure; evaluate the gallbladder if cholelithiasis is suspected.DailyMed (U.S. National Library of Medicine)

• Discontinue when pregnancy is recognised (or weigh ongoing therapeutic need); may cause fetal harm based on the statin mechanism of action.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Breastfeeding is not recommended during treatment.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Assess LDL-C as early as 2 weeks after starting or titrating; monitor INR with coumarins and digoxin levels on initiation.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)