سعر ACTOZONE 45MG 10 TAB. 2026

Pioglitazone 45 mg tablets, 10 tablets (AMOUN).

• Common adverse reactions (≥5%): upper respiratory tract infection, headache, sinusitis, myalgia, pharyngitis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Initiation in patients with established NYHA class III or IV heart failure.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Serious hypersensitivity to pioglitazone or any component.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: thiazolidinediones cause or exacerbate congestive heart failure; monitor for signs of heart failure.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hypoglycaemia risk when combined with insulin or insulin secretagogues; dose reduction may be needed.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Postmarketing reports of hepatic failure; not for type 1 diabetes or diabetic ketoacidosis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Gemfibrozil and other strong CYP2C8 inhibitorsIncrease pioglitazone exposure about 3-fold; limit pioglitazone to 15 mg daily.DailyMed (U.S. National Library of Medicine)

• Limited human data are insufficient to determine a drug-associated risk of major birth defects or miscarriage.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No information on presence in human milk or effects on the breastfed infant.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Pioglitazone: Thiazolidinedione that depends on the presence of insulin; decreases insulin resistance in the periphery and liver via PPAR-gamma agonism.