سعر جلوستازون 45 مجم 2022

Glustazon 45 mg tablets (pioglitazone) by Chemipharm (Egypt).

• Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus (thiazolidinedione / PPAR-gamma agonist).Population: Adults with type 2 diabetesDailyMed / Takeda

• Most common (≥5%): upper respiratory tract infection, headache, sinusitis, myalgia, pharyngitis. Edema and weight gain are dose-related; hypoglycemia more common with insulin/secretagogues.International label, equivalent formulation · DailyMed / Takeda

• Initiation in patients with established NYHA Class III or IV heart failure; known hypersensitivity to pioglitazone or any component.International label, equivalent formulation · DailyMed / Takeda

• BOXED WARNING — thiazolidinediones including pioglitazone can cause or exacerbate congestive heart failure. Monitor for edema/dyspnea/rapid weight gain. Also: hypoglycemia with insulin/secretagogues, hepatic failure reports, possible bladder cancer risk (avoid active bladder cancer), dose-related edema, fractures in women, macular edema.International label, equivalent formulation · DailyMed / Takeda

• Strong CYP2C8 inhibitors (e.g. gemfibrozil)MajorIncrease pioglitazone exposure ~3-fold; limit dose to 15 mg daily.DailyMed / Takeda
• CYP2C8 inducers (e.g. rifampin)ModerateMay decrease pioglitazone concentrations; adjust diabetes therapy based on response.DailyMed / Takeda

• Limited human data; poorly controlled diabetes increases maternal/fetal risks. Animal studies at high multiples of human exposure showed delayed parturition/reduced viability at high doses.International label, equivalent formulation · DailyMed / Takeda
• Unknown whether pioglitazone is present in human milk; present in rat milk. Weigh benefits vs potential risks.International label, equivalent formulation · DailyMed / Takeda

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